For more than 20 years, scientists and researchers have used the ISS to conduct research into biological, physical, biomedicine, materials, and Earth and space science. The extension of operations to 2030 will continue to return benefits to the United States and to humanity as a whole while preparing for a successful transition of capabilities to one or more commercially-owned and -operated LEO destinations. It is NASA’s goal to be one of many customers of these commercial destination providers, purchasing only the goods and services the agency needs. Commercial destinations, along with commercial crew and cargo transportation, will provide the backbone of the low-Earth orbit economy after the International Space Station retires.