www.biotools.us
SUMMER UPDATE
As most of our collaborators, colleagues and customers are returning to their physical places of work, we wanted to send an update as many of you have asked – which we greatly appreciate.

Considered an essential business, our contract lab stayed open supporting pharmaceutical industry: either it was an urgent check on chirality for possible COVID-19 treatment or protein conformation of a potential vaccine; continued research and manufacturing of new drugs or regulatory fling support. Regardless of modality – big molecule or small, we are humbled that we can help.

We also took the time to help our local neighbors with hand sanitizers when none were available. We are chemists – so we could! We developed, delivered to the elderly and donated.

And as social distance and time allowed we continued to manufacture our award-winning instruments and accessories!

Back in stock (or about to be) are all your favorites and our best-sellers!

Short-pathlength cell for FT-IR and VCD/CD.
Universally compatible with every
FT-IR spectrometer.
(available in July)
BioCell holder jacket with flow adapters for temperature controlled studies. AccuTune provides precision tightening.
(available now)
Pelltier based temperature controller
Designed for use in FT-IR spec­trometers with large circular BioCell™ windows. The controller can be controlled either manually or through computer interface.
(available end of July - early August)
The µ-RIM slide is a stainless steel substrate for Raman and Reflectance IR Spectroscopy. The highly reflective surface has no detectable Raman or IR background signal. This substrate is ideal for measuring small quantities of material, especially from dilute solutions in polar solvents (such as water).
(Also known as Drop Coat Deposition Raman (DCDR) slides.).
(available now)
And we couldn’t have an update without providing a list of
recent papers on VCD & ROA:

Featuring a review by Prof. Nafie based on his 2019 Chirality Medal Award address.
‌
Vibrational optical activity: From discovery and development to future challenges
By Nafie Laurence A
From Chirality (2020), 32(5), 667-692, Language: English, Database: MEDLINE
Up-to-date in 2020, there were over 50 papers published with VCD (Vibrational Circular Dichroism) and  16 papers with ROA (Raman Optical Activity) or VOA (as searched by us). U nfortunately we can not list them all here - so click on the links above to see them all!

Three reviews were published on the topic of VOA:
‌
Structure of Condensed Phase Peptides: Insights from Vibrational Circular Dichroism and Raman Optical Activity Techniques
By Keiderling, Timothy A.
From Chemical Reviews (Washington, DC, United States) (2020), 120(7), 3381-3419. Database: CAPLUS, DOI:10.1021/acs.chemrev.9b00636

Recent Trends in Chiroptical Spectroscopy: Theory and Applications of Vibrational Circular Dichroism and Raman Optical Activity
By Krupova, Monika; Kessler, Jiri; Bour, Petr
From ChemPlusChem (2020), 85(3), 561-575. Language: English, Database: CAPLUS, DOI:10.1002/cplu.202000014

A new horizon for vibrational circular dichroism spectroscopy: a challenge for supramolecular chirality
By Sato, Hisako
From Physical Chemistry Chemical Physics (2020), 22(15), 7671-7679. Language: English, Database: CAPLUS, DOI:10.1039/d0cp00713g
And two papers where VCD was used for determination of absolute configuration with BioTools scientists as co-authors:
‌
Isolation, Total Synthesis, and Absolute Configuration Determination of Renoprotective Dimeric NAcetyldopamine-Adenine Hybrids from the Insect Aspongopus chinensis
By Ding Wei-Yi; Qin Hong-Bo; Yan Yong-Ming; Meng Xiao-Hui; Xu Te; Cheng Yong-Xian; Nafie Laurence A; Dukor Rina K
From Organic letters (2020), , Language: English, Database: MEDLINE

Eudesmacarbonate, a Eudesmane-Type Sesquiterpene from a Marine Filamentous Cyanobacterial Mat (Oscillatoriales) in the Florida Keys
By Lydon Christina A; Berry John P; Mathivathanan Logesh; Sanchez Juanita; Dos Santos Larissa A H; Sauvage Thomas; Gunasekera Sarath P;
Paul Valerie J
From Journal of natural products (2020), , Language: English, Database: MEDLINE
BioTools | Empower Your Research.