Issue #11 | March 2026

Announcements

All New Sites Are Randomizing!

Congratulations to our four newest sites, Temple University, University of North Carolina, University of Texas Southwestern, and Johns Hopkins University, for completing onboarding and entering the enrollment and randomization phase!

Patient Payment Emails

What's new?

Patients will now receive an email from MyDataHelps when a study compensation payment has been processed. To enable this, the DCC added three new segments (0.17–0.19) in MyDataHelps Designer that trigger an automatic email notification at 7am EST, the day after the DCC processes a payment. The email informs patients that a check from the University of Michigan will arrive within 1–2 weeks.

Why did we make this change?

To better communicate to patients when they should expect payments and from which institution (UM)
Reduce confusion from patients asking where their payment is
Provide information to CRCs about when patients payments were processed

What to look for:

New segments in MyDataHelps Designer
New custom fields in the Participant Info tab of each patient's MDH profile
Paid Dates and compensation amounts in the Payment tab of MQUARK

New Segments in MyDataHelps Designer

Custom fields in MyDataHelps Designer Patient Profile

Updated Payment Tab in MQUARK

Operational Update

Target Randomization: 13,000

Randomization counts as of March 23, 2026

Institution	Total Randomized	Institution	Total Randomized
Brigham and Women’s Hospital	238	University of California San Francisco	1,722
Dartmouth-Hitchcock Medical Center	150	University of Michigan	927
Duke University Hospital	445	University of North Carolina	7
Henry Ford Detroit	232	University of Pennsylvania	114
Johns Hopkins	19	University of Texas Southwestern	11
Massachusetts General Hospital	156	University of Utah	653
MD Anderson	1,011	University of Virginia Health System	250
NYU Langone Medical Center	156	University of Washington	223
Oregon Health Science University	172	Wake Forest School of Medicine	258
Stanford University	41	Washington University	1,075
Temple University	20	Weill Cornell Medical College	642
University of Arkansas	208	Yale New Haven Hospital	845
		TOTAL:	9,575

96.8%

POD1 QoR15

99.5%

POD1 or POD30 Brice

98.2%

TIVA Adherence

99.8%

INVA Adherence

Personnel Change Form

New team members joining? Current team members departing? Please make sure to complete the Personnel Change Form so new hires get the training information they need, and systems access for people no longer on the team can be removed.

To Withdraw or Not to Withdraw...After Randomization

If a patient is already randomized, there are very few valid reasons to withdraw the patient. Per clinical trial best practices, we MUST report the trial outcomes for all randomized patients in the final analysis.

Don't Withdraw!

If a patient is randomized, then the anesthesia clinician or surgeon decide they do not want the patient to receive the randomized result, DO NOT WITHDRAW the patient. Keep the patient in the study and complete follow up surveys as normal. The patient can still contribute valuable information to the study and receive compensation for their participation.

Other invalid reasons for withdrawing after randomization:

Non-responsive to outreach
PI Concern
Research team logistics
Post-consent screen fail

Withdraw!

Valid reason to withdraw a patient after randomization:

Patient request
Deceased
Case or general anesthesia cancelled
Post-randomization screen fail

Fire Drill! Where (and What) is Your Downtime Packet?

Do you know where your downtime packet is? What about the newest members of your team?

Every site was mailed a packet of paper documents and envelopes for use in the event that randomization or other time-sensitive activities could not be completed in MQUARK or MyDataHelps.

Each packet includes:

10 sealed envelopes for manual randomization
MQUARK DOS form
SAE forms
UB-CAM survey
3D-CAM survey
EQ-5D-5L survey
WHODAS 2.0 survey
QoR-15 survey
Modified Brice survey

Getting to Know the Team - Brigham & Women's Hospital

Luigino Nascimben, MD

Brigham and Women's Hospital

Dr. Nascimben is the PI of three skilled research coordinators dedicated to the success of THRIVE. He works as the Director of Anesthesia Clinical Affairs for Mass General Brigham at Brigham & Women’s Hospital and as a cardiac anesthesiologist. He was a former cardiologist and clinical pharmacologist at the University of Padua, Italy before training as an anesthesiologist in US. He previously participated in many clinical trials in cardiac surgery and cardiology, testing new medications for heart failure and coagulation. He loves THRIVE for the opportunity to expand TIVA to areas of anesthesia where it is less prevalent and for the data that this clinical trial will provide regarding recovery from anesthesia.

He is always thrilled when our anesthesia residents ask questions about the study and about the pharmacology behind inhaled and intravenous medications used for anesthesia.

Sula Nasra

Brigham and Women's Hospital

Sula joined the Department of Anesthesia as a research fellow after graduating from medical school and is currently preparing to apply to residency. Working on the THRIVE study has allowed her to connect with patients while also seeing how research can improve recovery after surgery. She has especially valued following participants over time and contributing to their recovery, even if it’s just by being a familiar and supportive presence.

Fun fact: Sula loves traveling and exploring new places, and she has made it a tradition to bring back a magnet from each trip, so her fridge is slowly running out of space!

Getting to Know the Team - University of Washington

Karen Domino, MD

University of Washington

Karen Domino, M.D., is a board certified anesthesiologist at UW Medical Center and a UW professor of Anesthesiology and Pain Medicine and adjunct professor of Neurological Surgery.

Dr. Domino strives to provide state-of-the-art, yet personal, perioperative care to the neurosurgical and trauma patient.

Dr. Domino earned her M.D. at the University of Michigan. Her clinical and research interests include pulmonary physiology, quality assurance, neuroanesthesia and trauma anesthesia.

In her free time Dr. Domino enoys parenting, hiking, camping, cooking and gardening.

Alexandra "Sasha" Luce

University of Washington

Sasha grew up in the Washington D.C area. She obtained her undergraduate degree in psychology and her graduate degree in clinical research management. She has worked in the clinical research field at the University of Washington for about 10 years now. She has two cats that she adores.

THRIVE is the first study Sasha has ever worked on as a CRC. She wanted to be part of something that could help improve patient safety and care. THRIVE taught her how to evaluate delirium, and interact with patients from recruitment to follow-ups. It got her to branch out of her comfort zone of just data entry. It challenged her to help improve her communication skills with both her team and with patients. She still has a lot to learn, but she values the experience gained working on this important research study.

Fun fact about myself: Sasha is dyslexic, which means she interprets written words or language differently. She can read backwards as well as she can read forwards. She has great pattern recognition skills, detecting patterns in someone’s writing and can spotting errors inconsistencies in data quickly. She learned to take her dyslexia and use it as a strength instead of a weakness.

Suggestion Box

We would love to hear from you! Please let us know if there is a team member you would like to recognize or celebrate in the next newsletter, or if there are other updates you would like to know about.

Funded by

Contract 2020C3-21106