eNews from The Methodology Center
December 2015

A recent paper in Addictive Behavior provides insight into the mechanisms that encourage and maintain nicotine dependence. The authors apply time-varying effect modeling (TVEM) and other methods to examine the association between nicotine dependence and the impact of smoking on mood.

Sara Vasilenko and Rebecca Evans-Polce

We are growing, and that is creating employment opportunities. We have openings for a postdoctoral researcher, a research associate, and an administrative director for The Center. We love working here; come join us or pass this along to a friend who is looking for a great opportunity.


We are pleased to announce the release of a web applet for planning  factorial experiments and fractional factorial experiments. This applet produces a list of random numbers that can be used to assign subjects to experimental conditions. Subjects are spread as evenly as possible across conditions. Factorial experiments are useful for selecting the components to be included in an intervention when scientists are following the multiphase optimization strategy (MOST)


Despite the many problems associated with alcohol abuse, relatively few people in the United States receive treatment for alcohol use disorders. Using smartphones to deliver interventions will allow more people to be treated and will reduce the cost of treatment. Methodology Center researchers received a new grant from the National Institute on Alcohol Abuse and Alcoholism to develop just-in-time adaptive interventions (JITAIs) that will provide each individual with the proper treatment when it is needed. 


The Methodology Center 2015-16 Annual Report is now available online. Our annual report contains concise descriptions of our research projects to give readers an overview of our mission, history, and research projects in just a few minutes. This year's report focuses on the five-year research plan for our new NIDA P50 grant and other new research projects. 


In a recent issue of the Society for Behavioral Medicine's Outlook newsletter, Methodology Center Investigator Kari Kugler spoke with Bonnie Spring, director of the Center for Behavior and Health at Northwestern University's Feinberg School of Medicine. They discuss the application of the  multiphase optimization strategy (MOST) to develop  Opt-In, an adult obesity intervention.


We have scheduled a training on optimization of behavioral and biobehavioral interventions. Topics include the multiphase optimization strategy (MOST); factorial and fractional factorial screening experiments; the sequential, multiple assignment, randomized trial, (SMART). The training will be held May 16-20, 2016, in Bethesda, MD. Registration information to follow.

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