Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of stromal cells in the tumor microenvironment. TAMs play a crucial role in tumor growth, invasion and migration, angiogenesis and immunosuppression. Consequently, the TAM-targeting therapies are particularly of significance in anti-cancer strategies.

To facilitate related drug development, ACROBiosystems has released a high-quality immune checkpoint proteins expressed in macrophage, including CD47, SIRPα, CD24, Siglec-10, LILRBs, etc. All those products are suitable for immunization, antibody screening, species cross-verification, and other applications. 

●   High homogeneity: HPLC verified high homogeneity

●  High bioactivity verified by ELISA / SPR / BLI / FACS

●  Suitable for immunization, neutralizing antibody screening and more

●  More options: CD47&SIRPα inhibitor screening kit

● Multiple species& labeled: Human, Mouse, Cynomolgus；PE/biotin labeled

●   High purity: SEC-MALS verification purity>90%

●   Binding activity of CD24&Siglec-10 verified by FACS

●   High bioactivity verified by ELISA / SPR / BLI / Cell based assay

●   Multiple species available: Human, Mouse, and Cynomolgus species are available to be used in species cross-verification.

●   High-purity: purity is verified by SDS-PAGE (>95%) and MALS (>90%).

●   Bioactivity is verified by ELISA and SPR assays; Affinity is verified by antibody and ligand binding assays.

●   LILRB1、LILRB2、LILRB3、LILRB4、LILRB5