The CCTS Investigator            
Accelerating Discoveries Toward Better Health
December 2018    
CCTS Hosts 2018 Annual Scientific Meeting
The Center for Clinical and Translational Science (CCTS) welcomed more than 200 attendees on Dec. 4 to the 2018 Annual Scientific meeting, Teaming Up on Science for a Healthier Ohio.

Attendees were joined by experts in addiction, opioid use disorder, Ohio’s health initiatives, team science, and more, and were invited to a poster presentation by 49 Ohio State researchers.

In addition, keynote speaker, Richard Harris , an award-winning NPR journalist and author of the book, Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions, discussed the importance of rigor and reproducibility in science.

An exciting part of the meeting featured very successful facilitated table talks. A future publication is planned to highlight these discussions.
Tools of the Trade: Understanding the Review Process, Grants and Manuscripts
When: Tuesday, February 5, 2019
Time: 8 AM to Noon
Where: BRT room 115

The Center for Clinical & Translational Science presents “Fund Me! Publish Me!” Investigators with years of experience on NIH study sections will inform attendees about: the administrative process of grant review at agencies; the reviewer perspective; and interpreting and responding to critiques. Journal editors will then address participants on how they can get their research published, addressing issues such as choosing a journal; the review process at journals; and writing responses to reviewer comments. Those most likely to benefit from attending are junior faculty, postdocs, and graduate students.

For questions or more information, please contact Heather Mesko-Ryba

Pet Hero Apollo was enrolled in one of the clinical trials for dogs with osteosarcoma at the Blue Buffalo Veterinary Clinical Trials Office in March of 2017. The clinical trial Apollo is part of is a randomized study that evaluates if orally administered rapamycin following Standard of Care improves long-term disease control. 

We currently have 11 clinical trials for different types of cancer including lymphoma, transitional cell carcinomas, osteosarcoma, solid tumors and mast cell tumors.

Please visit our website for a complete list of our current trials.
The College of Medicine Office of Research is hosting its next Clinical Research Professional Training Series:

Tuesday, January 10, 2019
DHLRI 170
9:00 - 10:00 am

Upcoming Session : HIPAA Breaches in Research
Speakers: Jennifer Elliott, Privacy Officer, OSUWMC
Jamie Nelson, Senior Systems Consultant, Data Security


Register now for these upcoming FAME sessions!

Staying Current in the Midst of Rapid Technological Advancement
Tues., Jan. 22, 2019, 9-10am
L045 James Cancer Hospital
Primary Audience: All Research Faculty
Aligns to FAME Competencies: Professionalism & Technical Skills; Outcomes; Organizational Awareness

CRISPR, 3D printing and AI are just a few technologies revolutionizing research. Not every technology gets as much publicity, staying up-to-date can be challenging. Join panelists who share their experiences and the technologies they are using in their research programs. Register by Jan. 18.


StrengthsFinder and DISC: Discover Your Best Self
Wed., Feb. 13, 2019, 7:30-11:30am
L045 James Hospital Conference Room
Primary Audience: All Faculty
CME: This event is certified for 2 AMA PRA Category 1 Credits

Have you ever paused to consider how to maximize your potential at work? This workshop, featuring both the Clifton StrengthsFinder and DISC assessments, helps teams and individuals discover natural patterns of thinking, feeling and behaving as well as behavioral styles. Prior to the session, you will complete both assessments. You’ll receive results/interpretation during the workshop to enable personal and professional insights.

The 18th annual  College of Medicine Trainee Research Day  is scheduled to take place Thursday, April 11. All College of Medicine faculty, staff and students are invited to attend.

Trainee Research Day provides an exciting opportunity for faculty, staff and students to appreciate the research being conducted in biomedical science by College of Medicine trainees of the Wexner Medical Center. More than 350 posters representing the work of these promising researchers will be on display throughout the day in the Biomedical Research Tower.

Two Online Master's Programs for Clinical and Preclinical Researchers
Develop  skills in clinical trial design, clinical pharmacology and toxicology, or advanc e  your career in clinical research administration . Choose one of two  flexible, 100% online master's programs: The  MS Pharmacology  program is designed for clinicians and students with a bioscience background. The  Master of Applied Clinical and Preclinical Research  is open to students with any background.  We are  currently accepting applications through February 1, 2019 for summer 2019 enrollment  (classes begin May 2019).

For more information on these programs or the admissions process, please visit MACPR or Ohio State Online.
Do you have questions about using an external IRB or making Ohio State the single IRB for your multi-site study? Join the Office of Responsible Research Practices and the Center for Clinical and Translational Science as we host walk-in office hours on Tuesday's from 12:30 am - 4:30 pm at the CCTS, room 259.
 
Submission to Western IRB under the Revised Common Rule
The Office of Responsible Research Practices, the Western IRB (WIRB), and the Center for Clinical and Translational Science are presenting a session about Western IRB oversight of Ohio State human subjects research with WIRB representative, Christopher Gennai. The presentation will:
  • Provide an overview of the Ohio State and WIRB submission processes
  • Navigate within the Ohio State and WIRB platforms
  • Explore revised Common Rule submission and review considerations
  • Describe required submission components
  • Review tips for successful submissions

The session will be held on Wednesday, January 30, 2019 , from 8:00am to 9:30am in the Biomedical Research Tower , Room 115, 460 West Twelfth Avenue.
The session is also available for live stream attendance.
 
Ohio Innovation Exchange connects universities, industry
The Ohio Department of Higher Education’s new Ohio Innovation Exchange (OIEx) connects industry with faculty, students, equipment and facilities available at Ohio’s research universities. OIEx provides extensive search functionality and an intuitive interface. This pilot includes engineering, health sciences and natural and mathematical sciences, with plans to add other disciplines and universities/colleges. Faculty may manage any data issues with their profiles  here. 

Please email all questions.

Accessing Research Data Office Hours - i2b2 and IHIS/IW data
Data Core within the Dept. of Biomedical Informatics can assist you in your Research Data needs and our analysts are available to provide their expertise on any questions regarding i2b2 access, data availability within i2b2, IHIS/EPIC or pre IHIS/IW tables, Honest Broker or research data in general.

The CCTS offers open office hours for i2b2 and Research Data consultations on Wednesdays from 1:00-3:00pm in 260 Prior Hall.

IRB Submission Assistance
The Office of Responsible Research Practices (ORRP) is offering assistance for Biomedical and Cancer researchers who prepare IRB submissions. Open office hours are held on Wednesdays from 12:30-4:30 pm in the CCTS suite, room 259, Prior Hall. Appointments are recommended; walk-ins are also accepted.

These individualized sessions are intended to help navigate IRB forms, policies, and review procedures. You can schedule an appointment by contacting Brandie Dickens.

ORRP continues to offer specialized assistance with single IRB review and IRB reliance Tuesday afternoons at the same location.
Call for Proposals: T rial Innovation Network
What makes a good Trial Innovation Network proposal?

The Trial Innovation Network is looking for study projects with:
  • Principal Investigators who are willing to partner with the TIN through the project lifecycle
  • Innovations in operations
  • Multiple sites
  • Inclusion of many populations
  • Academic evidence to improve clinical trial design

Any full-time faculty member at The Ohio State University and/or Nationwide Children’s Hospital is eligible to submit a study proposal to the Trial Innovation Network through the  CCTS TIN Hub Liaison Team.

To submit a proposal or for questions about the Trial Innovation Network, please contact Hub Liaison Team Administrator, Angela Sow via email or at (614) 247-7732.
Call for Submissions: European Conference on Science, Art and Culture - ECSAC ' 19 in Antalya/Turkey
International “IV th  European Conference on Science, Art & Culture” provides an ideal academic platform for researchers to present the latest developments, research findings, ideas, and applications about all aspects of science and culture. The purpose of this international conference is to come together with scientific studies scholars working in different disciplines, to exchange knowledge and experiences and thus to prepare the ground for multidisciplinary studies. The conference will bring together leading academic scientists, researchers and scholars in the domain of interest from around the world.

In addition, the full text papers presented at the conference will be prepared independently of the conference, and each of them will be published as an independent section in the book entitled ‘Academic Works in the Fields of Science, Culture and Art’. The academic book will be published by “Gece Kitaplığı Publishing”, which is a well-known ‘’international publisher’’ according to the recognition stated by the T.C. Interuniversity Council Presidency (ICP) in April 2018 in the terms of associate professorship application. Book chapters will be formed with a multidisciplinary approach. The work that may be included in the book as a section will be selected among the applications.
The requirements for the book section application:
  1. The language of the book should be Turkish or English.
  2. The book chapters should be up to 20 pages.
  3. Free of charge.
  4. The rules of writing for the book section are available on our web page.

The conference will take place in  April 18-21, 2019 which will be held on by Gece Akademi Publishing House in Antalya, Turkey.

Nationwide Children’s Hospital has become home to the most innovative clinical trials in the nation, and oftentimes, globally. In an effort to create an intellectual community to foster compliance and lower institutional risk, NCH is offering an expanded clinical research course series on a variety of topics. Individuals completing all sessions will receive a certificate of Clinical Research Competency.

Courses will be held in the main Clinical Research Conference Room located on the 6 th  floor of the Tower building (T 6220) unless otherwise noted, and are eligible for CE credits with ACRP or SoCRA.

For more information on 2018 courses, dates offered, and registration, please visit  the ANCHOR website (this is a NCH Internal Site) for the Clinical Research Competency Series.
The OSU Office of Research provides a campus-wide subscription to an excellent newsletter on Research Grantwriting News. Writers are experts in research/proposal development and this resource should be required reading for anyone preparing a grant proposal. Recommendations are especially helpful to those who are new to grant writing or want to enhance their grantsmanship skills.

If you are thinking about your next research project, we encourage you to schedule a research funding consult and learn how to use SPIN, an extensive research funding opportunity database. SPIN contains over 40,000 opportunities from more than 10,000 sponsors. With SPIN, you will learn how to:
 
  • Create and save customized searches that generate daily email funding alerts
  • Organize and share funding announcements with colleagues
  • Access an extensive Keyword list, allowing for greater flexibility in your searches
  • Quickly locate Federal or non-Federal programs
  • Locate all types of funding information, e.g., travel grants, fellowships, and other sponsored programs
 
All Ohio State faculty, staff, and students are able to create an account in SPIN. Please visit  http://go.osu.edu/funding  for step-by-step instructions.
The Department of Health and Human Services announced an  Interim Final Rule That Delays Both the Effective Date and General Compliance Date of the Revisions to the Federal Policy for the Protection of Human Subjects  (the Common Rule) for a minimum of six months with future delay possible.

The Regulatory Guidance for Academic Research of Drugs and Devices (ReGARDD) Program offers an innovative and organized platform in which regulatory expertise can be shared across academic intuitions. ReGARDD provides academic researchers with the regulatory tools and resources necessary to successfully navigate the pathway from discovery to clinical implementation of new drugs, biologics and medical devices. We use a two-pronged approach:
 
  • A shared CTSA website that is comprised of helpful tools, templates, decision trees, and educational resources to support academic investigators’ regulatory needs,
  • A regional forum of regulatory experts from the four institutions involved in the program. The role of the forum is to strengthen the regulatory affairs workforce at each institution by providing exposure to a broad array of regulatory knowledge and a platform to share best practices, and discuss complex regulatory issues.

The ReGARDD program is a collaboration between the regulatory affairs specialists from North Carolina Institutions that receive funding from the NIH Clinical and Translational Science Awards (CTSA) Program. These CTSA hub institutions are the University of North Carolina at Chapel Hill and partner RTI International, Duke University, and the Wake Forest School of Medicine.

2019 Community Engagement Conference
Join us for this two-day conference of insights and new connections that will expand your professional horizons on January 23-24, 2019 .

You will interact with a broad range of community engagement practitioners to share diverse ideas, engage in robust discussion and envision new partnerships in the pursuit of a resilient and sustainable future.
  • Register by Dec. 7 for the early-bird price of $85
  • Special registration for students is only $30 for two days — or $20 for one day

The keynote speaker will be Mary Robinson , former president of Ireland, founding member of The Elders and leader of the Mary Robinson Foundation - Climate Justice.

Registration is now open for the 2019 Translational Science Conference.
More than 1,100 trainees, researchers and federal program officers are coming together for  Translational Science 2019  March 5-8 in Washington, DC.  

Here's what you can expect over your four days in the nation's capital:

  • Expanded time for workshops, mini-symposia, and networking time
  • Keynote presentations from key thought leaders like Thomas R. Insel, MD, Heidi Rehm, PhD, FACMG and Sharon Terry
  • A best in class abstract hall, featuring the most innovative research from 550+ presenters
  • Opportunities to learn more about the FDA and NIH, and advocate for clinical and translational science on Capitol Hill 

Early bird registration ends Friday, January 18. Register today to reserve your spot and save!
Rare diseases affect an estimated 30 million Americans. On Feb. 28, 2019, NIH will host an event to raise awareness about these diseases, the people they affect and current research collaborations.

Sponsored by NCATS and the NIH Clinical Center,  Rare Disease Day at NIH  will take place from 8:30 a.m. to 4:00 p.m. ET in the main auditorium of the Natcher Conference Center, Building 45 on the main campus in Bethesda, Maryland. Speakers include NCATS Director Christopher P. Austin, M.D.; NIH Clinical Center CEO James K. Gilman, M.D.; and NCATS Office of Rare Diseases Research Director Anne R. Pariser, M.D.

The PhRMA supports research and early career endeavors of scientists in drug discovery and development, and recently published application materials for three 2019 award programs. Click on one below to learn more.


For more than a decade now,  DREAM Challenges  have motivated and incentivized biomedical research teams around the world to collaborate to develop innovative solutions to pressing scientific questions. DREAM has successfully run over 50 Challenges in multiple disease and biomedical research domains spanning basic, translational, and clinical research.

Now, the National Center for Data to Health (CD2H) is bringing the DREAM Challenge platform to the CTSA Program to help accelerate informatics innovation across the translational spectrum. We are planning to run a series of CTSA-relevant DREAM Challenges focused on computational- and informatics-themed problems and we are eager for your ideas! We’re therefore excited to announce the launch of the first ever 
$100K CD2H Idea Competition.

This is an opportunity to turn your scientific question into a DREAM Challenge to be tackled by teams across the world. If your idea is selected, you will receive up to a $100,000 subcontract to run a DREAM Challenge in collaboration with the CD2H! 

Call for Proposals : Consortium for Advancement of Neuromusculoskeletal Science and Locomotion (CANSL)
CANSL is accepting applications for pilot proposals requesting funding up to $7,500 over 1 year for projects related to neuromusculoskeletal regeneration, recovery, and rehabilitation. The PI may be from any department at OSU, but a co-investigator from the College of Veterinary Medicine is required to be eligible for this funding. Multi-disciplinary teams (both across and outside of the University) and novel collaborations are strongly encouraged and will greatly enhance enthusiasm for an individual’s proposal.

Applicants should provide a 1-2 page “scope of work” briefly detailing the project goals and justifying how funds would be utilized. Included within this description should be a section outlining plans for future external funding and potential for on-going collaborations with the College of Veterinary Medicine.

Proposals should be submitted electronically to Sarah Moore by January 15 th for consideration.

Grants prioritized for funding will be selected by the CANSL executive committee and announced on or before February 15, 2019.
NCATS invites innovators to submit novel design solutions for its ASPIRE A Specialized Platform for Innovative Research Exploration Design Challenges. Supported through the  NIH Helping to End Addiction Long-term , the goal of the Challenges is to reward and spur innovative and catalytic approaches toward solving the opioid crisis through development of: (1) novel chemistries; (2) data-mining and analysis tools and technologies; and (3) biological assays that will revolutionize discovery, development and pre-clinical testing of next generation, safer and non-addictive analgesics to treat pain, as well as new treatments for opioid use disorder and overdose.

NCATS anticipates that this integrated platform ultimately can be generalized to address many of the roadblocks in automated chemistry.
 
The Challenges open Dec. 31, 2018, and submissions are due to  challenge.gov  by Noon ET on May 31, 2019.

PSAG 2.0: A new and expanded Patient Safety Advancement Grant RFA
The Ohio State University Wexner Medical Center’s Department of Quality and Patient Safety and University Self Insurance Program (USIP), with support from  the Center for Clinical and Translational Science (CCTS), would like to announce the Patient Safety Advancement Grant (PSAG) program for 2019. The Patient Safety Advancement Grant program aims to help develop grass roots involvement in advancing patient safety in hospital associated studies at the medical center by soliciting and funding ideas generated by faculty, staff and residents. Funding will be available for projects that further advance healthcare quality through innovative approaches to improve patient outcomes or prevent patient harm.

Henceforth, PSAG will be offered two times a year and the expanded program will include new tracks and levels of funding so we can increase the variety and number of projects. Past awardees who completed their projects successfully are welcome to apply for funding for implementation or follow-up studies.

Proposal Deadline: January 31, 2019 

Questions? Please contact Dr. Tanya Mathew , CCTS Pilot Administrator.
Funding Opportunity from I-Corps@Ohio - Accelerating the Commercialization of Ohio’s University-Based Technologies
Who? Call for proposals from teams of clinicians and researchers from any Ohio institute of higher learning who are working on innovative health-related devices, diagnostics, medicines, vaccines, software, testing procedures and systems to solve a health/clinical problem and improve the quality of human life

What?   $15K Grant along with the I-Corps@Ohio Summer Program with coaching to conduct customer interviews and to explore product-market fit and de-risk the technology commercialization venture at an early stage. “If you want to save two years, the I-Corps@Ohio program will save you that much time. In the seven-week program, you will find out if anyone really wants your technology.” Stuart Schaefer, Mentor, I-Corps@Ohio

I-Corps@Ohio , a grant funded entrepreneurship program in the state of Ohio ,  formally established a Medtech Track in 2015 in collaboration with the Cleveland Clinic and the National Institute of Health Center for Accelerating Innovation (NCAI). Selected teams are awarded $15K to participate in the summer program looking to validate the commercial potential of their research discoveries and how the commercial potential can drive future funding, collaboration and funding opportunities. More than 30 Medtech teams have completed the I-Corps@Ohio program and many rate the program as one of the best learning experiences they have engaged in. Program instructors include clinical researchers, biotech and medtech experts from around the country with more than 40 years of experience coaching Medtech teams. Visit the I-Corps@Ohio website for submission instructions and to view the RFP which contains information on the required time commitment.  The submission portal is open. 

Submission Deadline: January 15, 2019 

For questions, please contact Nikki Modlich
NEW in 2018: Fast-Track Funding Option for Fellows/Residents
As of October 1, 2018, a new “fast-track” (expedited) option for intramural funding before the end of the calendar year will be available for fellows/residents. Fellows/residents will be required to complete the same intramural funding application process (for either new or resubmitted applications) for submission by the December 1 deadline . However, rather than the standard 10-12 week timeline for award decisions, fast-track applications will undergo an expedited review process and applicants will receive their funding notifications by the end of the year, allowing funds to be allocated in 2018, rather than 2019. Three grants to fellows/residents, for up to $10,000 each, will be available for 2018.

For more information, visit the ANCHOR website (Nationwide Children's Hospital intranet/campus access only) or contact Intramural Funding .
The OSU CCTS is excited to announce that The OSU Office of Research’s CarmenWiki listing of all internal funding opportunities has been updated with a new column titled “ Includes Human Health ”. Thanks to Jeff Agnoli and his team, this resource will now help translational scientists to quickly find grants that are applicable to human health.

Funding Opportunities from the NIH.

Read about the latest translational science news, opportunities, and announcements in the latest edition of the NCATS e-Newsletter and the NIH's Weekly Funding Notice.



Learn more about PCORI through their blog, video room, news releases, and other resources.

Discover the latest news in translational science and grant opportunities from the Association for Clinical and Translational Science's monthly newsletter. 

When you sign up as a member of the OSU CCTS, you are entitled to become a member of The Association for Clinical and Translational Science at no cost .

As a member of the ACTS, you have access to a wide variety of benefits and tools to assist you with your research. These benefits include:

  • Discounted registration for the Translational Science Meeting
  • Email updates and web access to relevant translational science topics
  • Access to the ACTS newsletter, the ACTS Connection
  • Access to articles in the Journal of Clinical and Translational Science, published by Cambridge University Press
  • Opportunities for development and participation in committees and special interest groups