Welcome to the Fall 2020 Houston Methodist Hospital Department of Pathology and Genomic Medicine Newsletter: The Laboratory Report. If you have contributions or feedback for upcoming newsletters, please email us.

Roger L. Bertholf, PhD, was awarded Mastership designation by the American Society for Clinical Pathology (ASCP) at their 2020 Virtual Annual Meeting this September. ASCP Mastership is an elite designation that recognizes ASCP members who have made “a significant contribution to pathology through sustained service to the profession and to the Society.”

Amongst his many contributions to the ASCP, Dr. Bertholf has served since 2012 as the editor-in-chief of the ASCP’s journal, Laboratory Medicine. Of his Mastership designation, Dr. Bertholf said: “I have been involved with the ASCP for nearly my entire career, beginning with my first Workshop for Laboratory Professionals in 1993. When I was selected in 2012 as editor of Laboratory Medicine, one of the two scientific journals published by the ASCP, it provided me with an opportunity to make a substantive contribution to the society’s reputation for promoting scholarly activity. Their recognition of my contributions with the ASCP Mastership Award is among the most professionally and personally gratifying honors I have received.”

Eric Salazar, MD, PhD, was recognized by NBC News in a September feature as a “Latino Hospital Hero.” The piece spotlighted Dr. Salazar’s early life in rural South Texas, his educational background, and the work he is currently performing at the forefront of SARS-CoV-2 pandemic research in the form of convalescent plasma treatment for severely ill COVID-19 patients. In the article, Dr. Salazar credits his parents and their work ethic for his successful career. The article quotes a 2018 study by the Association of American Medical Colleges that less than 6% of all active physicians are of Latinx heritage, putting Dr. Salazar in an elite group of medical professionals

Dr. Salazar currently serves as Co-Medical Director of Transfusion Medicine and Medical Director of Coagulation Laboratories at HMH, and he is an Assistant Professor of Pathology and Genomic Medicine at the HMAI and Assistant Professor Pathology and Laboratory Medicine at WCMC. Dr. Salazar’s research in the area of convalescent plasma therapy has been featured in numerous journals, including an article in The American Journal of Pathology that represented the first media unicorn (>1 billion unique views) for Houston Methodist Hospital.

Hurricane season is almost over! We are incredibly proud of how everyone, especially our laboratory staff, has responded and prepared as Hurricane Laura threatened our community. Hurricane Laura was expected to make landfall as a Category 4 hurricane near Sabine Pass, approximately 80 miles east of our hospital. We prepared for potentially significant sustained winds and rain that could cause downed power lines and debris in the roads, making safe commuting an issue. In order to maintain social distancing and keep employees safe, some of the private offices were utilized as resting rooms by our great laboratory ride-out team. We were fortunate that Hurricane Laura had very little impact on our area, but we remain alert for potential future storms and actively work on hospital-wide and laboratory-specific contingency plans. Although Tropical Storm Beta threatened us with heavy rain, HMB remained open.

Laboratory construction project underway at HMB.

HMTW is pleased to report that we underwent a successful CAP inspection on October 5, under the leadership of Dr. Ruba Halloush!

We have welcomed new Chief Techs for day shift and evening shift: welcome Nora Somuyiwa and Buena Umali!

Todd Eagar, PhD, Associate Medical Director of Histocompatibility and Immunogenetics Laboratory, reports that the Laboratory recently was granted approval by the American Society for Histocompatibility and Immunogenetics (ASHI) for the use of Next Generation Sequencing (NGS). NGS has become a mainstay of molecular testing and Human Leukocyte Antigen (HLA) HLA typing. The laboratory applied for accreditation to use NGS-based HLA typing. For their validation studies, lab members typed over 100 samples, including 20 unknown samples, with 100% concordance observed with prior typing results.

ASHI accreditation for NGS testing is the culmination of much hard work on the part of the HLA team. Congratulations to Dr. Eagar, Dr. Nicholas DiPaoloa, Dr. Michael Greenwood, and all of the staff who made this accomplishment possible!

Pathology Assistant Monica Lemos, with Surgical Pathology Fellow Ziad El-Zaatari, MD, created and presented an educational lecture via videoconferencing on the challenges of grossing gynecological specimens to a group of pathologists in Mozambique, Africa. The presentation, based on Ms. Lemos’ highly-successful “Atlas of Surgical Pathology Grossing,” gave attendees a wealth of practical tips and knowledge for performing grossing in low-resource settings, and was part of the inaugural session of Project ECHO (Extension for Community Healthcare Outcomes) in Portuguese-speaking regions of Africa.

Spearheaded by Dr. Marcia Edelweiss of Memorial Sloan Kettering Cancer Center, Project ECHO’s Lusophone Africa project provides local healthcare professionals in isolated or research-constrained areas of Portuguese-speaking Africa with the opportunity to interact with colleagues from the United States and around the world to enhance knowledge and learn valuable diagnostic strategies.

Many thanks to Ms. Lemos and Dr. El-Zaatari for their commitment to global pathology education!

Residents and fellows in our Department’s 2019-20 cohort of trainees, as well as faculty from specialties in both Anatomic and Clinical Pathology,are thrilled to announce the publication of their article “Pathology Trainee Redeployment and Education during the COVID-19 Pandemic: An Institutional Experience” in the September issue of Academic Pathology.

The article was born from the experience of our Department’s trainees and faculty re-entering the laboratories during the first wave of the current COVID-19 pandemic. Jessica Thomas, MD, PhD, Associate Medical Director of the Molecular Pathology Diagnostic Laboratory, Program Director of the Molecular Genetic Pathology Fellowship, Associate Program Director for Clinical Pathology in the Pathology Residency Program, Assistant Professor of Clinical Pathology at the HMAI and Weill Cornell, and corresponding author of the article, said that at the beginning of the COVID-19 pandemic, “many AP service lines saw overall decreased case volumes, while the clinical pathology laboratories had multiple efforts in support of Houston Methodist’s COVID19 response. The Department’s trainee redeployment was an opportunity for our Pathology residents and fellows to be involved in our response to COVID-19. They became involved in a number of activities and projects, including COVID-19-related assay development and validations, the convalescent plasma trial, and informatics and research projects, just to name a few. The COVID-19 virtual seminar series allowed trainees to both learn from each other and share their experiences during redeployment. It was wonderful working closely with the trainees and providing such a valuable educational experience for them during a difficult time.”

Suzanne Z. Powell, MD, Vice-Chair for Education, Chief of Neuropathology, Director of the Pathology Residency Program and Neuropathology Fellowship Program, Professor of Pathology at the HMAI and Weill Cornell, and author in the article said, “As the first wave of the COVID-19 pandemic occurred, the Department divided our residents and fellows into two groups, with one working from home and the other in the hospital. Originally planned for exchange after two weeks, the second two-week period began as planned, but quickly escalated to not only bringing all trainees back to the hospital, but with a redeployment plan of trainees to support the COVID-19 response. The case volumes in anatomic pathology had plummeted and a surge in testing for COVID-19 as well as treatment trials were necessary. The manuscript highlighted all of the changes and the adaptability of the trainees and the faculty to meet the needs of the patients of Houston.”

During the first wave of the pandemic, first author and 2019-20 Chief Resident Paloma Monroig-Bosque, MD, PhD, was the trainee responsible for laboratory management. Her duties included rounding to all laboratories and working as needed in each lab. She began to notice many changes and adaptations in practice that were rapidly occurring because of COVID-19. Dr. Monroig-Bosque stated: “I was very proud to see how the trainees were included in every step of the way. The focus and care for our training was impressive. I sought to try to read what people in pathology were doing regarding involving the trainees in the process and absolutely nothing was published. I thought it would be a good idea to publish the stepwise approach we had used in order to possibly help other programs during this continuing pandemic. It was so much work, but we are so proud of it.”

The article is available online now.

The Office of Academic Development (OAD) and Laboratory Report editorial staff are pleased to welcome our newest co-editors in chief to the Laboratory Report team!

After moving to the United States, she completed a combined Anatomic and Clinical Pathology residency at Baylor College of Medicine in 2009, a Cytopathology Fellowship at The University of Texas MD Anderson Cancer Center in 2010, and a Surgical Pathology Fellowship at Houston Methodist in 2011. Her special interest is in Gynecologic and Obstetric Pathology. She was honored with the Robert E. Scully Young Investigator Award in 2014 by the International Society of Gynecological Pathologists for authoring the best printed article in the International Journal of Gynecological Pathology on her introduction of a new classification system for endocervical adenocarcinoma. Dr. Diaz De Vivar has recently been recertified by the ABP in anatomic pathology, clinical pathology and cytopathology.

Dr. Mukul Divatia received his M.B.B. S. degree with honors from the Maharaja Sayajirao University of Baroda, India in 2002. After completing his pathology residency from the same institution, he undertook a two year fellowship at Tata Memorial Hospital In Mumbai, a sister institute of MD Anderson Cancer Center. Following a brief stint in private practice in his hometown Baroda, he relocated to the United States where he completed a fellowship in Ophthalmic Pathology as well as a residency in Anatomic and Clinical Pathology at the Houston Methodist Hospital, followed by another fellowship in Genitourinary Pathology at Cedars Sinai Medical Center in Los Angeles where he was also the awarded the Sports Spectacular Distinguished Fellow award for his research. Dr. Divatia moved back to Houston thereafter and has been a faculty member with our department since July 2015. He serves on the editorial board of Archives of Pathology and Laboratory Medicine and is a reviewer for several peer reviewed publications in pathology. Dr. Divatia is an ardent teacher and inveterate student of surgical pathology with a special interest in hepatopathology. When he is not signing out cases, he likes to travel and explore novel cuisines and cultures.

Dr. Diaz De Vivar and Dr. Divatia have graciously agreed to serve as co-editors-in-chief and provide oversight and guidance for this and future publications of the Laboratory Report. Many thanks to our previous editor-in-chief, April Ewton, MD, for her years of service in this role!

Sasha Pejerrey, PhD, Lead Scientific Writer; Adrienne Winston, Scientific Writer; and Heather McConnell, PhD, Scientific Writer, presented as part of the first-ever virtual Health Science Practicum for students from HISD’s Jones Futures Academy. The practicum was sponsored by the HMRI’s Office of Graduate Studies and Trainee Affairs, and gave students the opportunity to interact firsthand with professionals in a variety of scientific endeavors with the goal of encouraging curiosity and engagement on the part of the students.

The Office of Academic Development (OAD) of the Department of Pathology and Genomic Medicine is available and fully staffed during the current SARS-CoV-2 pandemic to assist department members with editing manuscripts, grants, posters, presentations, and more. Please contact Sasha Pejerrey at spejerrey@houstonmethodist.org or 713.441.5889; Adrienne Winston at awinston@houstonmethodist.org or 713.441.3395; or Heather McConnell at hmcconnell@houstonmethodist.org 0r 346.238.4346. There is no charge for the OAD’s services, and no project is too big or too small!

Long SW, Olsen RJ, Christensen PA, Bernard DW, Davis JJ, Shukla M, Nguyen M, Saavedra MO, Yerramilli P, Pruitt L, Subedi S, Kuo HC, Hendrickson H, Eskandari G, Nguyen HAT, Long JH, Kumaraswami M, Goike J, Boutz D, Gollihar J, McLellan JS, Chou CW, Javanmardi K, Finkelstein IJ, Musser JM. Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area. mBio. 2020 Oct 30;11(6):e02707-20. https://doi.org/10.1128/mBio.02707-20

Wu L, Xia M, Sun X, Han X, Zu Y, Jabbour EJ, et al. High levels of immunoglobulin expression predict shorter overall survival in patients with acute myeloid leukemia. European Journal of Haematology. 2020 Oct 1;105(4):449-459. https://doi.org/10.1111/ejh.13466

Cathcart SJ, Greene EP, Powell SZ, Arumanayagam AS, Rivera AL, Tawil R, Appel SH, Cykowski MD. Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient. Journal of Neuropathology and Experimental Neurology. 2020 Oct 1;79(10):1130-1133. https://doi.org/10.1093/jnen/nlaa066

Zhu L, Yerramilli P, Pruitt L, Saavedra MO, Cantu CC, Olsen RJ, Beres SB, Waller AS, Musser JM. Genome-wide assessment of streptococcus agalactiae genes required for survival in human whole blood and plasma. Infection and Immunity. 2020 Oct;88(10). e00357. https://doi.org/10.1128/IAI.00357-20

Zhan Y, Debs D, Khan MA, Nguyen DT, Graviss EA, Khalaf S, et al. Natural History of Functional Tricuspid Regurgitation Quantified by Cardiovascular Magnetic Resonance. Journal of the American College of Cardiology. 2020 Sep 15;76(11):1291-1301. https://doi.org/10.1016/j.jacc.2020.07.036

Salazar E, Kuchipudi SV, Christensen PA, Eagar T, Yi X, Zhao P, Jin Z, Long SW, Olsen RJ, Chen J, Castillo B, Leveque C, Towers D, Lavinder JJ, Gollihar J, Cardona JA, Ippolito GC, Nissly RH, Bird I, Greenawalt D, Rossi RM, Gontu A, Srinivasan S, Poojary I, Cattadori IM, Hudson P, Josleyn NM, Prugar L, Huie KE, Herbert AS, Bernard DW, Dye JM, Kapur V, Musser JM. Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization. The Journal of Clinical Investigation. 2020 Sep 10. https://doi.org/10.1172/JCI141206

Jakowenko N, Nguyen S, Ruegger M, Dinh A, Salazar E, Donahue KR. Apixaban and rivaroxaban anti-Xa level utilization and associated bleeding events within an academic health system. Thrombosis Research. 2020 Dec;196:276-282. https://doi.org/10.1016/j.thromres.2020.09.002

Hong BYB, Bean A, Vickers A, Cykowski M, Lee AG. Fourth Nerve Palsy Due to Neurocysticercosis. Journal of Neuro-Ophthalmology: The Official Journal of the North American Neuro-Ophthalmology Society. 2020 Sep 1;40(3):414-416. https://doi.org/10.1097/WNO.0000000000000785

Thrall MJ, Vrbin C, Barkan GA, Monaco SE, Pambuccian SE, Pantanowitz L, et al. Small core needle biopsies in cytology practice: a survey of members of the American Society of Cytopathology. Journal of the American Society of Cytopathology. 2020 Sep 1;9(5):310-321. https://doi.org/10.1016/j.jasc.2020.06.002

Anand K, Phung TL, Bernicker EH, Cagle PT, Olsen RJ, Thomas JS. Clinical Utility of Reflex Ordered Testing for Molecular Biomarkers in Lung Adenocarcinoma. Clinical Lung Cancer. 2020 Sep;21(5):437-442. https://doi.org/10.1016/j.cllc.2020.05.007

Warmke L, Vining D, Ward J, Lin M, Ro JY, Zhang M. Paratesticular clear cell carcinoma of müllerian origin—A case report. Human Pathology: Case Reports. 2020 Sep;21. 200401. https://doi.org/10.1016/j.ehpc.2020.200401

Southon SB, Beres SB, Kachroo P, Saavedra MO, Erlendsdóttir H, Haraldsson G, Yerramilli P, Pruitt L, Zhu L, Musser JM, Kristinsson KG. Population genomic molecular epidemiological study of macrolide-resistant streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a large clonal population with a pbp2x mutation conferring reduced in vitro β-Lactam Susceptibility. Journal of Clinical Microbiology. 2020 Sep;58(9). e00638-20. https://doi.org/10.1128/JCM.00638-20

Li M, Liu W, Bauch T, Graviss EA, Arduino RC, Kimata JT et al. Clearance of HIV infection by selective elimination of host cells capable of producing HIV. Nature Communications. 2020 Aug 13;11(1). 4051. https://doi.org/10.1038/s41467-020-17753-w

Stroup BM, Marom R, Li X, Hsu CW, Chang CY, Truong LD, et al. A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance. Human Molecular Genetics. 2020 Aug 3;29(13):2171-2184. https://doi.org/10.1093/hmg/ddaa107

Olsen RJ, Zhu L, Musser JM. A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis. American Journal of Pathology. 2020 Aug 1;190(8):1625-1631. https://doi.org/10.1016/j.ajpath.2020.04.014

Xu L, Polski A, Prabakar RK, Reid MW, Chevez-Barrios P, Jubran R, et al. Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival. Molecular Cancer Research. 2020 Aug 1;18(8):1166-1175. https://doi.org/10.1158/1541-7786.MCR-19-1262

Lunsford KE, Agopian VG, Yi S, Nguyen DT, Graviss EA, Harlander-Locke MP, et al. Delayed Implantation of Pumped Kidneys Decreases Renal Allograft Futility in Combined Liver-Kidney Transplantation. Transplantation. 2020 Aug 1;1591-1603. https://doi.org/10.1097/TP.0000000000003040

Arora K, El-Zaatari ZM, Schwartz MR, Ro J. Lesions of anogenital mammary-like glands: Four cases including novel pathologic and immunohistochemical observations. Annals of Diagnostic Pathology. 2020 Aug 1;47. 151551. https://doi.org/10.1016/j.anndiagpath.2020.151551

Shields C, Kim M, Lally S, Chévez-Barrios P, Shields J. Eye cancer in a young male with a vaping history. Indian Journal of Ophthalmology. 2020 Aug;68(8):1699-1701. https://doi.org/10.4103/ijo.IJO_27_20

Xia R, Varnado S, Graviss EA, Nguyen DT, Cruz-Solbes A, Guha A, et al. Role of thromboelastography in predicting and defining pump thrombosis in left ventricular assist device patients. Thrombosis Research. 2020 Aug;192:29-35. https://doi.org/10.1016/j.thromres.2020.03.016

Salazar E, Perez KK, Ashraf M, Chen J, Castillo B, Christensen PA, Eubank T, Bernard DW, Eagar TN, Long SW, Subedi S, Olsen RJ, Leveque C, Schwartz MR, Dey M, Chavez-East C, Rogers J, Shehabeldin A, Joseph D, Williams G, Thomas K, Masud F, Talley C, Dlouhy KG, Lopez BV, Hampton C, Lavinder J, Gollihar JD, Maranhao AC, Ippolito GC, Saavedra MO, Cantu CC, Yerramilli P, Pruitt L, Musser JM. Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma. American Journal of Pathology. 2020 Aug;190(8):1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

Xu-Monette ZY, Zhang H, Zhu F, Tzankov A, Bhagat G, Visco C, Dybaker K, Chiu A, Tam W, Zu Y, Hsi ED, You H, Huh J, Pnzoni M, Ferreri AJM, Moller MB, Parsons BM, vn Krieken JH, Piris MA, Winter JN, Hagemeister FB, Shahbaba B, De Dios I, Zhang H, Li Y, Xu B, Albitar M, Young KH. A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL. Blood Advances. 2020 Jul 28;4(14):3391-3404. https://doi.org/10.1182/bloodadvances.2020001949

Mishra A, Singh VK, Actor JK, Hunter RL, Jagannath C, Subbian S, Khan A. GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity? Frontiers in Immunology. 2020 Jul 23;11. 1599. https://doi.org/10.3389/fimmu.2020.01599

Makthal N, Do H, Wendel BM, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M. Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence. Infection and Immunity. 2020 Jul 21;88(8). https://doi.org/10.1128/IAI.00097-20

Eubank TA, Long SW, Perez KK. Role of Rapid Diagnostics in Diagnosis and Management of Patients With Sepsis. The Journal of Infectious Diseases. 2020 Jul 21;222(Supplement_2):S103-S109. https://doi.org/10.1093/infdis/jiaa263

Manouchehri N, Hussain RZ, Cravens PD, Doelger R, Greenberg BM, Okuda DT, Forsthuber TG, Eagar TN, Stuve O. Limitations of cell-lineage-specific non-dynamic gene recombination in CD11c.Cre⁺ITGA4^fl/fl mice. Journal of Neuroimmunology. 2020 Jul 15;344. 577245. https://doi.org/10.1016/j.jneuroim.2020.577245

Nwokedi U, Nguyen DT, Meisenbach LM, Chihara R, Chan EY, Graviss EA, et al. Short-term outcome of routine use of EndoFLIP during hiatal hernia repair. Surgical Endoscopy. 2020 Jul 14. https://doi.org/10.1007/s00464-020-07788-x

Bishop-Freeman SC, Bertholf RL, Powers RH, Mayhew LC, Winecker RE. False-Positive Enzymatic Alcohol Results in Perimortem Specimens. Laboratory Medicine. 2020 Jul 8;51(4):394-401. https://doi.org/10.1093/labmed/lmz082

Khan MA, Yang EY, Nguyen DT, Nabi F, Hinojosa J, Jabel M, Nagueh SF, Graviss EA, Shah DJ. Examining the Relationship and Prognostic Implication of Diabetic Status and Extracellular Matrix Expansion by Cardiac Magnetic Resonance. Circulation: Cardiovascular Imaging. 2020 Jul 1;13(7). e011000. https://doi.org/10.1161/CIRCIMAGING.120.011000

Suo L, Liu S, Vega I, Thrall M. Extramedullary multiple myeloma involving the liver and periportal lymph node, diagnosed by EUS-FNA in a patient with cirrhosis. Diagnostic Cytopathology. 2020 Jul 1;48(7):657-661. https://doi.org/10.1002/dc.24416

Soliman BG, Nguyen DT, Chan EY, Chihara RK, Meisenbach LM, Graviss EA et al. Impact of da Vinci Xi robot in pulmonary resection. Journal of Thoracic Disease. 2020 Jul 1;12(7):3561-3572. https://doi.org/10.21037/jtd-20-720

Vahidy FS, Bernard DW, Boom ML, Drews AL, Christensen P, Finkelstein J, et al. Prevalence of SARS-CoV-2 Infection Among Asymptomatic Health Care Workers in the Greater Houston, Texas, Area. JAMA Network Open. 2020 Jul 1;3(7):e2016451. https://doi.org/10.1001/jamanetworkopen.2020.16451

Ali AB, Khan NA, Nguyen DT, Chihara R, Chan EY, Graviss EA, et al. Robotic and per-oral endoscopic myotomy have fewer technical complications compared to laparoscopic Heller myotomy. Surgical Endoscopy. 2020 Jul 1;34(7):3191-3196. https://doi.org/10.1007/s00464-019-07093-2

Iso T, Rizk E, Harris JE, Salazar E, Heyne K, Herrera E, et al. Viable Hemostasis Obtained With Prothrombin Complex Concentrate in Patients Who Refuse Standard Allogeneic Blood Transfusion and Undergo Complex Cardiac Surgery: A Case Series. A&A Practice. 2020 Jul 1;14(9):e01276. https://doi.org/10.1213/XAA.0000000000001276

Long SW, Saavedra MO, Christensen PA, Musser JM, Olsen RJ. Human Infections Caused by Clonally Related African Clade (Clade III) Strains of Candida auris in the Greater Houston Region. Journal of Clinical Microbiology. 2020 Jul;58(7). e02063-19. https://doi.org/10.1128/JCM.02063-19

Robbins RJ, Thomas JS, Osuna PM, Shakil J. A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer. Case Reports in Endocrinology. 2020;2020. 7641940. https://doi.org/10.1155/2020/7641940

Lin MS, Ngo T, Schwartz MR, Mehta RR, Ayala AG, Ro JY. Anastomosing hemangioma of the breast: An unusual case at an unusual site. Journal of Breast Cancer. 2020;23(3):326-330. https://doi.org/10.4048/jbc.2020.23.e15

Szymanski TW, Weeks PA, Lee Y, Kumar S, Castillo B, Kar B, et al. Anticoagulation of impella with a bivalirudin purge solution. ASAIO Journal. 2020;E117-E120. https://doi.org/10.1097/MAT.0000000000001126

Suo L, Vega I, Thrall M. Cyto-histo correlations of plasmacytoid and micropapillary variants of high-grade urothelial carcinoma: do they fit well in The Paris System for reporting urinary cytology? Journal of the American Society of Cytopathology. 2020. https://doi.org/10.1016/j.jasc.2020.05.013

Lee J, Yoo Y, Park S, Cho MS, Sung SH, Ro JY. Double cocktail immunostains with high molecular weight cytokeratin and GATA-3: Useful stain to discriminate in situ involvement of prostatic ducts or acini from stromal invasion by urothelial carcinoma in the prostate. Journal of Pathology and Translational Medicine. 2020;54(2):146-153. https://doi.org/10.4132/jptm.2019.11.12

Timmons CF, Black-Schaffer WS, Naritoku WY, Powell SZ, Johnson KA, Brissette MD, et al. Entry of Graduates of US Pathology Residency Programs Into the Workforce: Cohort Data Between 2008 and 2016 Remain Positive and Stable. Academic Pathology. 2020;7. https://doi.org/10.1177/2374289520901833

Messer JA, Zuhour RJ, Haque W, Lewis GD, Schefler AC, Wong A, Bernicker EH, Chévez-Barrios P, Quan EH, Farach A, Butler EB, Teh BS. Eye plaque brachytherapy versus enucleation for ocular melanoma: an analysis from the National Cancer Database. Journal of Contemporary Brachytherapy. 2020;12(4):303-310. https://doi.org/10.5114/jcb.2020.98108

Eraso JM, Kachroo P, Olsen RJ, Beres SB, Zhu L, Badu T, Shannon S, Cantu CC, Saavedra MO, Kubiak SL, Porter AR, DeLeo FR, Musser JM. Genetic heterogeneity of the Spy1336/R28—Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis. PLoS ONE. 2020;15(3). e0229064. https://doi.org/10.1371/journal.pone.0229064

Ahmed A, Granillo A, Burns E, Glassner K, Naseem N, Force C, Crumley SM, Drew A. Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature. Case Reports in Medicine. 2020;2020. 8613840. https://doi.org/10.1155/2020/8613840

Dickinson KJ, Bass BL, Graviss EA, Nguyen DT, Pei KY. How learning preferences and teaching styles influence effectiveness of surgical educators. American Journal of Surgery. 2020. https://doi.org/10.1016/j.amjsurg.2020.08.028

Mindikoglu AL, Coarfa C, Opekun AR, Shah VH, Arab JP, Lazaridis KN, Putluri N, Ambati CR, Robertson MJ, Devaraj S, Jalal PK, Rana A, Goss JA, Dowling TC, Weir MR, Seliger SL, Raufman JP, Bernard DW, Vierling JM. Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis. Future Science OA. 2020;6(2). https://doi.org/10.2144/fsoa-2019-0124

Monroig-Bosque PDC, Hsu JW, Lin MS, Shehabeldin AN, Rogers JT, Kim CF, Kalsekar AG, Jin Z, Cara LR, Barbieri AN, El-Zaatari Z, Eskandari G, Sheu TG, Tomsula JA, Long SW, Zieske AW, Leveque CM, Salazar E, Mody DR, Schwartz MR, Cykowski MD, Yi X, Powell SZ, Thomas JS. Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience. Academic Pathology. 2020;7. https://doi.org/10.1177/2374289520953548

Karanth S, Nelson PT, Katsumata Y, Kryscio RJ, Schmitt FA, Fardo DW, Cykowski MD, Jicha GA, Van Eldik LJ, Abner EL. Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults. JAMA Neurology. 2020. https://doi.org/10.1001/jamaneurol.2020.1741

Musser JM, Beres SB, Zhu L, Olsen RJ, Vuopio J, Hyyryläinen HL, et al. Reduced in vitro susceptibility of Streptococcus pyogenes to β-lactam antibiotics associated with mutations in the pbp2x gene is geographically widespread. Journal of Clinical Microbiology. 2020;58(4). e01993-19. https://doi.org/10.1128/JCM.01993-19

Hao S, Lu X, Gong Z, Bassett RL, Hu S, Konoplev SN et al. The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma. Modern Pathology. 2020. https://doi.org/10.1038/s41379-020-00669-7

Choi JH, Ro JY. Retroperitoneal Sarcomas: An Update on the Diagnostic Pathology Approach. Diagnostics. 2020 Sep;10(9). 642. https://doi.org/10.3390/diagnostics10090642

Kim DK, Kim JW, Ro JY, Lee HS, Park JY, Ahn HK, et al. Plasmacytoid variant urothelial carcinoma of the bladder: A systematic review and meta-analysis of clinicopathological features and survival outcomes. Journal of Urology. 2020 Aug 1;204(2):215-223. https://doi.org/10.1097/JU.0000000000000794

Samaratunga H, Delahunt B, Srigley JR, Berney DM, Cheng L, Evans A, Furusato B, Leite KRM, MacLennan GT, Martignoni G, Moch H, Pan CC, Paner G, Ro J, Thunders M, Tsuzuki T, Wheeler T, van der Kwast T, Varma M, Williamson SR, Yaxley JW, Egevad L. Granular necrosis: a distinctive form of cell death in malignant tumours. Pathology. 2020 Aug;52(5):507-514. https://doi.org/10.1016/j.pathol.2020.06.002