The Latest in Opioid and Pain Research

Quarterly Newsletter, July, 2020

In the News...

COVID-19 and OPIOID USE DISORDER (OUD)

Over the past few months social distancing orders due to COVID-19 have altered resources for many of our most vulnerable populations, including those who struggle with Opioid Use Disorder.

Although local data is still being consolidated regarding the efffects that the COVID-19 has on OUD in Massachusetts, preliminary data predicts grim results.

Resources and Information for COVID-19 and OUD

Brigham Health Bridge Clinic

Massachusetts Recovery Hotline

COVID-19 Guidance for Opioid Treatment Programs

COVID-19 recovery resources

COVID-19 and Opioid Use Disorder Research

For more information regarding OUD/COVID-19 contact POPI at [email protected] .

RACIAL DISPARITIES IN TREATMENT OF PAIN

The recent national and world wide media attention focused on racism and inequity towards African-Americans has prompted the Brigham family to reimagine the ways in we approach healthcare.

Like many other racial and ethnic disparities research amongst chronic diseases,POPI aims to take a closer look at how chronic pain is evaluated in people of color. Studies suggest that racial bias can affect how doctors assess and treat pain in black people.

Brigham Funding Opportunities

McGraw Family Opioid Innovator Award

We are excited to announce that Brigham & Women’s Hospital will host a Shark Tank event in Oct 2020 to fund two innovative and high-risk/high- impact projects in the basic, clinical, digital and translational realms through the McGraw Family Innovator Awards (open to opioid-related research).

Up to two non-renewable grants will be awarded on a competitive basis with award denominations of up to $50,000 and $25,000 respectively. LOI Due 7/22/20.

Stepping Strong Innovator Awards

Stepping Strong is accepting applications for the second annual Stepping Strong Injury Prevention Innovator Award.Priority will be given to proposals that address the innovative, multidisciplinary research in areas such as

Traffic safety, Interpersonal Violence,Older Adult Injury, Substance Use, Trauma-related outcomes and Disaster preparedness and prevention. Amount: Up to $100,000 Apply by: 8/15/20

Federal Funding Opportunities

NOSI: Research to Prevent Drug Use, Misuse and Addiction

The National Institute on Drug Abuse ( NIDA ) of special interest in research to: 1) develop and test strategies to prevent the initiation of substance use, progression to substance use disorders, and to prevent substance use-related conditions such as HIV; 2) develop and test processes or strategies to implement, scale and sustain evidence-based prevention in community, practice, and service systems, with an emphasis on settings that may be opportune given the prevalence of at-risk individuals; and, 3) develop methods to conduct prevention science.

Notice Number: NOT-DA-19-048

Due Date: Rolling

Cannabis, Prescription Opioid, or Prescription Benzodiazepine Drug Use Among Older Adults

The National Institute on Drug Abuse ( NIDA ) and National Institute on Aging ( NIA ) of special interest in grant applications to conduct rigorous research on cannabis and potentially addictive, psychoactive prescription drug use (specifically opioids and benzodiazepine) in older adults. This program will focus on two distinct older adult populations (over the age of 50): (1) individuals with earlier use onset of cannabis and the specified drug classes who are now entering older age, or (2) individuals who initiate use of cannabis and the specified drug classes after the age of 50. Insights gained from this initiative have the potential to inform the public and health care systems regarding use of cannabis and prescription opioids and benzodiazepines in older populations.

Notice Number: NOT-DA-20-014

Due Date: Rolling

NOSI: Implementation of Clinical Guidelines on Opioid Prescribing for Pain Management

This NOSI seeks applications that will test multifaceted implementation strategies for evidence-based clinical guidelines on opioid prescribing for pain management, in order to (1) increase guideline-concordant clinical care behaviors; (2) generate measurable, timely, and sustainable changes in clinical behavior across entire healthcare systems; and (3) improve patient outcomes.

Notice Number: NOT-DA-20-0 38

(FOA) Number: PAR-18-222

Amount: TBD

Due Date: Rolling

Accelerating the Pace of Drug Abuse Research Using Existing Data (R01 Clinical Trial Option)

Invites applications proposing innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of substance using behaviors (defined as alcohol, tobacco, prescription and other substances) and related disorders, prevention of substance use and HIV, and health service utilization.

(FOA) Number: PAR-19-368

Amount: Varies

Due Date: Rolling

NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Option)

Provide support for research Centers that (1) conduct drug abuse and addiction research in any area of NIDA’s mission, (2) have outstanding innovative science, (3) are multidisciplinary, thematically integrated, synergistic, and (4) serve as national resource(s) to provide educational and outreach activities to drug abuse research communities, educational organizations, the general public, and policy makers in the NIDA research fields.

Agency:NIDA

(FOA) Number: PAR-19-259

Amount: Up to $10 million

Due Date: September 2020

NOSI: Utilizing Telemedicine or Other Remote-Based Platforms to Develop and Support Treatments for Substance Use Disorders

stimulate research to evaluate the safety and efficacy of telemedicine or remotely provided treatments for SUD, and to develop tools for remote collection of data in clinical trials of treatments for SUD.

Notice Number: NOT-DA-20-058

Amount: Varies

Due Date: October, 2020

Addressing the Challenges of the Opioid Epidemic in Minority Health and Health Disparities Research in the U.S. (R01 Clinical Trial Optional)

Supports research to understand and reduce disparities in opioid care; and to determine the mechanisms for the variation in the prevalence of Opioid Use Disorder (OUD) in U.S. health disparities populations.

FOA: PAR-18-747

Amount: Varies

Due Date: Rolling

Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R21 Clinical Trial Optional)

The purpose of the Funding Opportunity announcement is to encourage grant applications from the scientific community on applying a biopsychosocial perspective to self-management of chronic pain. . Top research priority is to determine optimal approaches for use of self-management strategies in chronic pain. Applying a biopsychosocial perspective to self-manage chronic pain in anticipated to improve long-term outcomes and quality of life for affected individuals, families and communities.

(FOA) Number: PAR-18-946

Due Date: Rolling

Private Funding Opportunities

SAEMF Advanced Research Methodology Evaluation and Design (ARMED) Pilot Training Grant

The SAEMF ARMED Pilot Grant is intended to provide funding to support the development of a scientist in emergency medicine. Its specific goals are: 1. Provide support to an emergency medicine academician awardee for one year of mentored research experience. The award is intended to support the applicant in obtaining preliminary or pilot data for future grant submissions. 2. Enhance the likelihood of the selection of an academic and research career by the awardee. 3. Encourage the awardee’s academic development and involvement in emergency medicine research.

Agency: Society for Academic Emergency Medicine

Amount: Varies

Due Date: August 1, 2020

For more grant and funding opportunities visit https://www.saem.org/saem-foundation/grants

Charles Koch Foundation

Seeks to support research projects (e.g. papers, conferences, workshops, etc.) that addresses innovative ways to help individuals overcome substance use disorders, prevent drug overdoses, and increase the willingness of individuals to seek treatment for substance abuse. Explores the root causes of addiction and substance use disorders as well as innovative means to prevent substance abuse by remedying these root causes. Addresses the unintended consequences of current approaches to reduce drug overdoses and substance abuse. Examines solutions that offer a proactive approach to fighting addiction rather than a reactive approach focusing on treatment and recovery. Explores opportunities to reduce the stigma associated with substance use disorders and celebrate success in overcoming addiction and substance abuse.

Agency: T he Charles Koch Foundation

Amount: Varies

Due Date: Rolling

IASP Early Career Research Grants Program

The IASP Early Career Research Grant facilitates a development of young researchers just starting their careers as independent investigators.

Agency: International Association for the Study of Pain

Amount: $20,000

Applications for the 2021 grant cycle will open in early December 2020.

The Christopher D. Smithers Foundation, Inc. Grant

Educating the public that alcohol use disorder and opioid use disorder are respectable, treatable medical illness from which people can and do recover; encouraging prevention programs and activities, with an emphasis on high risk populations; and continually fighting to reduce and eliminate the stigma that is associated with the medical illness of addiction.

Agency: The Christopher D. Smithers Foundation, Inc.

Amount: Varies

For more information visit https://smithersfoundation.org/grants/

Mallinckrodt Grants

The Edward Mallinckrodt, Jr. Foundation is a private foundation that funds basic biomedical research in St Louis and throughout the United States. The mission of the Foundation is to support early stage investigators engaged in biomedical research that has the potential to significantly advance the understanding, diagnosis, or treatment of disease.

Annual submission deadline: August 1st

Amount: $60,000

For more information visit http://www.emallinckrodtfoundation.org/Application.html

Lasker Award

Individuals or organizations must meet at least one of the following selection criteria for the Lasker~Bloomberg Public Service Award: 1) significantly improving the public’s understanding of medical research, public health, or healthcare; 2) playing a major role in the support of policy, legislative, or other initiatives that accelerate progress in medical science or health; 3) providing critical and generous financial support for initiatives to enhance health or medical research; 4) generating support for medical science or public health; 5) significantly benefitting the lives of many people through public health practice.

Amount: Varies

Submission Date: November 2, 2020 - February 1, 2021

For more information visit http://www.laskerfoundation.org/about/award-nominations-1/

Fellowships and Nursing Funding Opportunities

Substance Use and Mental Health Services Administration (SAMHSA), the SAMHSA Substance Abuse Minority Fellowship

program provides a one-year (2nd year optional) fellowship to psychiatry residents who are at the PG3 level or higher and are committed to addressing minority psychiatric mental health issues .

Agency: American Psychiatric Association

Amount: $25,000- $28,000

Anticipated Due Date: Fall 2020

The Foundation for Addictions Nursing

The primary activities of FAN are to cultivate resources to advance the profession of addictions nursing, develop partnerships with individuals and organizations, and, together with the members of the organization, identify initiatives to advance the specialty.

For more information visit https://www.intnsa.org/about-us/fan/

Featured Innovator Publications

Bateman, Brian T.,M.D. -Anesthesiology Perioperative and Pain Medicine

Rates and Costs of Dispensing Naloxone to Patients at High Risk for Opioid Overdose in the United States, 2014–2018 July 2020

Drug Enforcement Agency 2014 Hydrocodone Rescheduling Rule and Opioid Dispensing after Surgery May 2020

Age and postoperative opioid prescriptions: a population-based cohort study of opioid-naïve adults April 2020

Aglio, Linda S.,MD, MS - Anesthesiology Perioperative and Pain Medicine

Long-Term Opioid Prescriptions After Spine Surgery: A Meta-Analysis of Prevalence and Risk Factor June 2020

Richard Urman, MD, -Anesthesiology Perioperative and Pain Medicine

Can enhanced recovery protocols impact non-opioid multimodal analgesia use in all surgical patients? June 2020

I s there a benefit in adding local anesthetics to intrathecal opioids for patients undergoing general anesthesia for laparoscopic surgery? June 2020

Recommendations for Managing Opioid-Tolerant Surgical Patients within Enhanced Recovery Pathways. May 2020

Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry An International Prospective, Observational Trial. April 2020

The opioid epidemic and how anesthesiologists can help. Spring 2020

Fischer, Michael A.,MD -Department of Medicine

Identification of barriers to safe opioid prescribing in primary care: a qualitative analysis of field notes collected through academic detailing June 2020

Boyer, Edward W.,MD,Ph.D.; Chai, Peter R.,MD -Emergency Medicine; Schreiber, Kristin L.,MD,Ph.D. -Anesthesiology Perioperative and Pain Medicine

A Brief Music App to Address Pain in the Emergency Department: Prospective Study. May 2020

Gilligan, Christopher J.,MD -Anesthesiology Perioperative and Pain Medicine

Is Buprenorphine Effective for Chronic Pain? A Systematic Review and Meta-analysis April 2020

Upcoming Events

POPI is proud to partner with and or sponsor events within BWH and the Boston health community at large. To learn more about participation at one of the events below contact Gloria Brand at [email protected].

Discover Brigham

November 12, 2020

Proposal Submissions Due September 14, 2020

National Recovery Month

September 2020 is National Recovery Month, Stay tuned for Brigham Health activities to be announced in August. For more information on how to participate or if you are interested in hosting an event please contact Gloria Brand at [email protected]. Read more about Recovery Month from SAMSHA at the link below.

SHARK TANK 2020

With generous support from the McGraw Family, POPI along with the Brigham Research Institute will Host a Virtual Shark Tank this October 20th featuring investigators of the Brigham interested in the opioid and pain research space!!

SAVE THE DATE - OCTOBER 20th

For more information contact, Gloria Brand, [email protected].