With eight floors of guest rooms plus a lobby, mezzanine, and service floor, the hotel served as a prototype for the vertical hotel casino. Its crown jewel was indisputably the 12th floor Sky Room, with floor-to-ceiling windows that overlooked the Truckee River, Virginia Street, and the Sierra Nevada mountains beyond.
At a time when few Reno hotels had their own nightclubs, the Mapes offered dining, dancing, and floor shows as well as gambling areas and cocktail lounges both on the main and top floors.
Many celebrities of that era stayed there, including Marilyn Monroe, Montgomery Clift and Clark Gable during the filming of The Misfits. President Harry Truman stayed there and many others.
The Sky Room at the top of the Mapes was a famous nightclub and stage where many of the biggest singers and entertainers of the time such as Frank Sinatra, Jimmy Durante and Milton Berle performed.
During the 1970s, brothel owner Joe Conforte paid a percentage to the Mapes Hotel bell men as they directed clients to his Mustang Ranch.