"Spousal Cognitive Status and Risk for Declining Cognitive Function and Dementia: The Atherosclerosis Risk in Communities Study," Mark Lee, Ryan T Demmer, Anna Kucharska-Newton, Beverly Gwen Windham, Priya Palta, Tetyana Shippee, Pamela L Lutsey
Abstract: Investigated the relationship between the cognitive status of participants' spouses and participants' own cognitive outcomes, controlling for mid-life factors. Discussion includes spousal cognitive status is not associated with poor cognitive outcomes independent of mid-life factors.
"Quality of Life and Mortality Outcomes for Augmentation Naïve and Augmented Patients with Severe Alpha-1 Antitrypsin Deficiency," Paul R Ellis, Kristen E Holm, Radmila Choate, David M Mannino, Robert A Stockley, Robert A Sandhaus, Alice M Turner
Abstract: Intravenous alpha-1 antitrypsin (AAT) augmentation therapy is the only specific treatment available for alpha-1 antitrypsin deficiency (AATD) related lung disease. It is widely used worldwide but remains unavailable to patients with AATD in the United Kingdom (UK).
While randomized trials of augmentation therapy have demonstrated biochemical efficacy and lung tissue preservation using CT densitometry, these studies were not adequately powered to demonstrate effectiveness in well-accepted clinical endpoints such as quality of life (QOL) or survival. We used large prospectively followed AATD patient populations in the US and UK to explore these important clinical endpoints.
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