The Research Scan Times

July 2022

Welcome to the inaugural issue of the Research Scan Times, a monthly newsletter collecting articles about the latest radiology research at Massachusetts General Hospital.

The Department of Radiology at Massachusetts General Hospital is home to one of the largest radiology research programs in the world, with roughly 270 research faculty dedicated to the development of biomedical imaging technologies and application of those technologies to a broad range of basic science and clinical questions. Given the size of the program, keeping track of the research underway in the department can be challenging.

This newsletter will compile articles from a host of sources, including Mass General News, Advances in Motion: Radiology, the Mass General Research Institute and more. Our hope is to be able to provide a monthly sampling of recent research findings, and perhaps encourage readers to explore further the work of the labs, centers and institutes that produced those findings.

Indeed, an equally important goal is to help foster a sense of community within the department and facilitate greater collaboration between its investigators. To this end, we will also highlight a different lab each month, providing a brief overview of the work the lab does.

Read on to learn the latest about Radiology Research at Mass General.

Image in the banner courtesy of the Martinos Center's Anand Kumar, PhD, Rahul Pal, PhD, and colleagues. See the relevant paper - and journal cover - here.

Articles

AI-Enabled, Ultrasound-Guided Device Could Save Lives on the Battlefield

Abdominal radiologist Theodore Pierce, MD, and colleagues in the Massachusetts General Hospital Department of Radiology and at MIT Lincoln Laboratory have developed an ultrasound-guided handheld robotic device that allows non-specialists—including combat medics in battlefield settings—to access deep arteries and veins for life-saving applications.

A New Data Driven-Model Could Provide a Powerful Policy Planning Tool to Combat the Nation's Opioid Crisis

Mohammad Jalali, PhD, and Erin Stringfellow, PhD,both of the MGH Institute for Technology Assessment, and colleagues have developed a simulation model that tracks the evolution of the opioid crisis for public policy analysis. The tool, known as SOURCE, projects that deaths from opioid overdose will increase over the next several years before declining as opioid use disorder decreases.

Lab Spotlight

AR/VR Lab

The Augmented Reality and Virtual Reality (AR/VR) Lab at Mass General fosters the development of innovative imaging processes by producing an immersive environment to improve patient-centered care, enhance diagnosis and treatment, and elevate medical education.

Learn more about the AR/VR Lab in this Advances in Motion article.

Journal Paper Summaries

COVID-19 Severely Interfered with Cancer Imaging in 2020

Lead author: Ottavia Zattra (Department of Radiology, MESH IO)
Senior Author: Marc D. Succi, MD (Department of Radiology, MESH IO)

Ethical Implications of Neuroimaging that Detects Covert Consciousness

Lead author: Michael J. Young, MD, MPhil
Senior author: Brian L. Edlow, MD (Martinos Center for Biomedical Imaging)

Humans of MGRI:

Sarasa Tohyama, PhD

A postdoctoral research fellow in the Martinos Center for Biomedical Imaging, Dr. Tohyama studies the brain mechanisms of patients with chronic pain and their response to different types of therapy, using diffusion tensor imaging (DTI) and fMRI approaches.

Learn more on the Mass General Research Institute's "Bench Press" blog.

Papers in High-Impact Journals

Includes papers published in June 2022

1: Tung EL, Avery LL. Effectively Incorporating Peer Teaching to Improve Radiology Education-Radiology In Training. Radiology. 2022 Jun;303(3):E32-E34. doi: 10.1148/radiol.212052. Epub 2022 Mar 8. PMID: 35258370.

2: Tian Q, Li Z, Fan Q, Polimeni JR, Bilgic B, Salat DH, Huang SY. SDnDTI: Self- supervised deep learning-based denoising for diffusion tensor MRI. Neuroimage. 2022 Jun;253:119033. doi: 10.1016/j.neuroimage.2022.119033. Epub 2022 Mar 1. PMID: 35240299.

3: Shapiro NL, Todd EG, Billot B, Cash DM, Iglesias JE, Warren JD, Rohrer JD, Bocchetta M. In vivo hypothalamic regional volumetry across the frontotemporal dementia spectrum. Neuroimage Clin. 2022 Jun 14;35:103084. doi: 10.1016/j.nicl.2022.103084. Epub ahead of print. PMID: 35717886; PMCID: PMC9218583.

4: Rubin DB, Hosman T, Kelemen JN, Kapitonava A, Willett FR, Coughlin BF, Halgren E, Kimchi EY, Williams ZM, Simeral JD, Hochberg LR, Cash SS. Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep. J Neurosci. 2022 Jun 22;42(25):5007-5020. doi: 10.1523/JNEUROSCI.2074-21.2022. Epub 2022 May 19. PMID: 35589391; PMCID: PMC9233445.

5: Riphagen JM, Suresh MB, Salat DH; Alzheimer's Disease Neuroimaging Initiative (ADNI). The canonical pattern of Alzheimer's disease atrophy is linked to white matter hyperintensities in normal controls, differently in normal controls compared to in AD. Neurobiol Aging. 2022 Jun;114:105-112. doi: 10.1016/j.neurobiolaging.2022.02.008. Epub 2022 Feb 28. PMID: 35414420.

6: Martins D, Dipasquale O, Veronese M, Turkheimer F, Loggia ML, McMahon S, Howard MA, Williams SCR. Transcriptional and cellular signatures of cortical morphometric remodelling in chronic pain. Pain. 2022 Jun 1;163(6):e759-e773. doi: 10.1097/j.pain.0000000000002480. Epub 2021 Sep 23. PMID: 34561394; PMCID: PMC8940732.

7: Lennartz S, Hokamp NG, Kambadakone A. Dual-Energy CT of the Abdomen: Radiology In Training. Radiology. 2022 Jun 21:212914. doi: 10.1148/radiol.212914. Epub ahead of print. PMID: 35727149.

8: Lee JH, Lee D, Lu MT, Raghu VK, Park CM, Goo JM, Choi SH, Kim H. Deep Learning to Optimize Candidate Selection for Lung Cancer CT Screening: Advancing the 2021 USPSTF Recommendations. Radiology. 2022 Jun 14:212877. doi: 10.1148/radiol.212877. Epub ahead of print. PMID: 35699582.

9: Kagan KBT, Guz D, Buchrits S, Gurion R, Vaxman I, Priss M, Groshar D, Catalano OA, Sherban A, Raanani P, Gafter-Gvili A, Bernstine H. Clinical and pathological predictors for FDG-PET/CT avidity in patients with marginal zone lymphoma-a retrospective cohort study. Eur J Nucl Med Mol Imaging. 2022 Jun;49(7):2290-2299. doi: 10.1007/s00259-022-05683-2. Epub 2022 Jan 26. PMID: 35079846.

10: Jungilligens J, Paredes-Echeverri S, Popkirov S, Barrett LF, Perez DL. A new science of emotion: implications for functional neurological disorder. Brain. 2022 Jun 2:awac204. doi: 10.1093/brain/awac204. Epub ahead of print. PMID: 35653495.

11: Jaramillo D, Duong P, Nguyen JC, Mostoufi-Moab S, Nguyen MK, Moreau A, Barrera CA, Hong S, Raya JG. Diffusion Tensor Imaging of the Knee to Predict Childhood Growth. Radiology. 2022 Jun;303(3):655-663. doi: 10.1148/radiol.210484. Epub 2022 Mar 22. PMID: 35315716; PMCID: PMC9131176.

12: Glasser MF, Coalson TS, Harms MP, Xu J, Baum GL, Autio JA, Auerbach EJ, Greve DN, Yacoub E, Van Essen DC, Bock NA, Hayashi T. Empirical transmit field bias correction of T1w/T2w myelin maps. Neuroimage. 2022 Jun 10;258:119360. doi: 10.1016/j.neuroimage.2022.119360. Epub ahead of print. PMID: 35697132.

13: Di Carli MF, Osborne MT. Targeted Molecular Imaging Sheds Light on Bioprosthetic Aortic Valve Thrombosis. JACC Cardiovasc Imaging. 2022 Jun;15(6):1121-1123. doi: 10.1016/j.jcmg.2022.03.025. PMID: 35680219.

14: Cooper LL, O'Donnell A, Beiser AS, Thibault EG, Sanchez JS, Benjamin EJ, Hamburg NM, Vasan RS, Larson MG, Johnson KA, Mitchell GF, Seshadri S. Association of Aortic Stiffness and Pressure Pulsatility With Global Amyloid-β and Regional Tau Burden Among Framingham Heart Study Participants Without Dementia. JAMA Neurol. 2022 Jun 6:e221261. doi: 10.1001/jamaneurol.2022.1261. Epub ahead of print. PMID: 35666520; PMCID: PMC9171656.

15: Bouchard HC, Sun D, Dennis EL, Newsome MR, Disner SG, Elman J, Silva A, Velez C, Irimia A, Davenport ND, Sponheim SR, Franz CE, Kremen WS, Coleman MJ, Williams MW, Geuze E, Koerte IK, Shenton ME, Adamson MM, Coimbra R, Grant G, Shutter L, George MS, Zafonte RD, McAllister TW, Stein MB, Thompson PM, Wilde EA, Tate DF, Sotiras A, Morey RA. Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury. Hum Brain Mapp. 2022 Jun 1;43(8):2653-2667. doi: 10.1002/hbm.25811. Epub 2022 Mar 15. PMID: 35289463; PMCID: PMC9057089.

16: Battal C, Gurtubay-Antolin A, Rezk M, Mattioni S, Bertonati G, Occelli V, Bottini R, Targher S, Maffei C, Jovicich J, Collignon O. Structural and Functional Network-Level Reorganization in the Coding of Auditory Motion Directions and Sound Source Locations in the Absence of Vision. J Neurosci. 2022 Jun 8;42(23):4652-4668. doi: 10.1523/JNEUROSCI.1554-21.2022. Epub 2022 May 2. PMID: 35501150; PMCID: PMC9186796.

17: Aly AH, Khandelwal P, Aly AH, Kawashima T, Mori K, Saito Y, Hung J, Gorman JH 3rd, Pouch AM, Gorman RC, Yushkevich PA. Fully Automated 3D Segmentation and Diffeomorphic Medial Modeling of the Left Ventricle Mitral Valve Complex in Ischemic Mitral Regurgitation. Med Image Anal. 2022 Jun 12;80:102513. doi: 10.1016/j.media.2022.102513. Epub ahead of print. PMID: 35772323.

18: Abrahamson EE, Kofler JK, Becker CR, Price JC, Newell KL, Ghetti B, Murrell JR, McLean CA, Lopez OL, Mathis CA, Klunk WE, Villemagne VL, Ikonomovic MD. 11C-PiB PET can underestimate brain amyloid-β burden when cotton wool plaques are numerous. Brain. 2022 Jun 30;145(6):2161-2176. doi: 10.1093/brain/awab434. PMID: 34918018.