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The Scan Times

An MGH Radiology Research Newsletter

September 2022

One of our greatest strengths in the Department of Radiology is the depth of our bench. The department is home to investigators doing phenomenal work across the research spectrum, from technology development to basic science studies and translational research. The opportunities for collaboration here are unparalleled.


Sometimes, though, such opportunities might be missed. Because of both our size - we are, after all, one of the largest radiology research programs anywhere - and our own productivity, keeping up with the latest findings from our colleagues can be a daunting task. To address this longstanding challenge, we are making a greater effort to keep you apprised of what's happening across the department. Exhibit A, of course, is the contents of this newsletter, including the monthly lab spotlight as well as the articles and other information about recent studies.


I encourage you to peruse the studies below, see what your colleagues have been doing, and maybe even reach out to them if reading about their work sparks an idea. You never know where it might lead!


And as always, please let us know about your latest breakthroughs and potential collaborative opportunities so we can highlight them across the department.


~ Bruce


Bruce Rosen, Vice-Chair for Research

Announcement from the Mass General Research Institute (MGRI)

Article: Smart Nanoparticle Shows That Intermittent Fasting May Protect the Heart From Damage During Chemotherapy

Article: Urgent Care Centers Reduce the Need for Emergency Department Visits in Patients With Neck Trauma

Article: Surgical Backlogs From COVID-19 Persist and Could Have Serious Healthcare Consequences Going Forward

Lab Spotlight: Precision Interventional and Medical Imaging (PIMI) Research Group

Journal Paper Summary

34 Papers in High-Impact and Other Important Journals

Image in the banner courtesy of Chao Liu, PhD, of the Martinos Center for Biomedical Imaging. The full image was one of 11 finalists from the 2021 MGRI Image Awards selected by the Russell Museum team for public display. Learn more here.

MGRI Announcement

Submissions Now Open for 2022 Image Awards

The Mass General Research Institute is now accepting submission for the 2022 Research Image Awards. MGHers are encouraged to share their best science images, as well as meaningful stories about the science and people who make the MGH one-of-a-kind. The deadline to submit is Monday, Oct. 31. Click here to learn more or submit an image.

Articles

Wrist-Worn Devices are Shown by Mass General Researchers to Be Cost-Effective for Screening of Atrial Fibrillation


A study by Jagpreet Chhatwal, PhD, director of the Institute for Technology Assessment in the Department of Radiology, shows that screening individuals for atrial fibrillation (AF) using wearable devices is more cost-effective than screening using conventional methods or than no screening at all.


Smart Nanoparticle Shows That Intermittent Fasting May Protect the Heart From Damage During Chemotherapy


A team lead by David Sosnovik, MD, director of the Program in Cardiovascular Imaging at the Martinos Center for Biomedical Imaging, recently developed a nanoparticle probe that can detect an indicator of heart damage from chemotherapy.


Urgent Care Centers Reduce the Need for Emergency Department Visits in Patients With Neck Trauma


Findings from a team of researchers in the Department of Radiology and a colleague in the Department of Medicine offer support that urgent care centers can cut costs and reduce emergency department overcrowding in this population.


Surgical Backlogs From COVID-19 Persist and Could Have Serious Healthcare Consequences Going Forward


A study by Marc Succi, MD, a clinician-researcher in the Department of Radiology, and colleagues suggests that a more thoughtful and strategic approach to deferring surgeries may be needed by hospitals in the future.

Lab Spotlight

Precision Interventional and Medical Imaging (PIMI) Research Group


Led by Dania Daye, MD, PhD, the PIMI Research Group serves to:


  • Advance precision and patient-centered medical care using artificial intelligence, machine learning and digital health
  • Leverage applications of these techniques in interventional radiology and medical imaging to enhance patient care


Learn more at the PIMI Research Group website.

Journal Paper Summary

MRI Shows Small Vessel Degeneration Is Bidirectional between Gray and White Matter


  • Lead author: Raquel Gutiérrez- Zúñiga, MD, PhD (Gordon Center for Medical Imaging)
  • Senior author: Jorge Sepulcre, MD, PhD, DMSc (Gordon Center for Medical Imaging)


Papers in High-Impact and

Other Important Journals


Includes papers published in August 2022



1: Beckers AB, van Oudenhove L, Weerts ZZRM, Jacobs HIL, Priovoulos N, Poser BA, Ivanov D, Gholamrezaei A, Aziz Q, Elsenbruch S, Masclee AAM, Keszthelyi D. Evidence for engagement of the nucleus of the solitary tract in processing intestinal chemonociceptive input irrespective of conscious pain response in healthy humans. Pain. 2022 Aug 1;163(8):1520-1529. doi: 10.1097/j.pain.0000000000002538. Epub 2021 Nov 15. PMID: 34799534.



2: Yendiki A, Aggarwal M, Axer M, Howard AFD, van Walsum AVC, Haber SN. Post mortem mapping of connectional anatomy for the validation of diffusion MRI. Neuroimage. 2022 Aug 1;256:119146. doi: 10.1016/j.neuroimage.2022.119146. Epub 2022 Mar 25. PMID: 35346838.



3: Tong Z, Chen X, Li Q, Fan Y, Zhang J. 18 F-FDG PET/CT Findings in a Patient With Primary Prostatic Synovial Sarcoma Combined With Adrenocortical Carcinoma. Clin Nucl Med. 2022 Aug 1;47(8):723-724. doi: 10.1097/RLU.0000000000004138. Epub 2022 Mar 30. PMID: 35353743.



4: Wang J, Nasr S, Roe AW, Polimeni JR. Critical factors in achieving fine-scale functional MRI: Removing sources of inadvertent spatial smoothing. Hum Brain Mapp. 2022 Aug 1;43(11):3311-3331. doi: 10.1002/hbm.25867. Epub 2022 Apr 13. PMID: 35417073; PMCID: PMC9248309.



5: Adeeb N, Dibas M, Diestro JDB, Cuellar-Saenz HH, Sweid A, Kandregula S, Lay SV, Guenego A, Renieri L, Sundararajan SH, Saliou G, Aslan A, Möhlenbruch M, Vranic JE, Regenhardt RW, Savardekar A, Mamilly A, Lylyk I, Foreman PM, Vachhani JA, Župančić V, Hafeez MU, Rutledge C, Waqas M, Parra Farinas C, Tutino VM, Inoue Y, Mirshahi S, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan A, Salehani A, Sporns P, Brehm A, Jones J, Psychogios M, Spears J, Lubicz B, Panni P, Puri AS, Pero G, Griessenauer CJ, Asadi H, Stapleton CJ, Siddiqui A, Ducruet AF, Albuquerque FC, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Limbucci N, Jabbour P, Cognard C, Patel AB, Dmytriw AA. Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge (WEB). Radiology. 2022 Aug;304(2):372-382. doi: 10.1148/radiol.212006. Epub 2022 Apr 19. PMID: 35438564.



6: Wu KC, Tamborini D, Renna M, Peruch A, Huang Y, Martin A, Kaya K, Starkweather Z, Zavriyev AI, Carp SA, Salat DH, Franceschini MA. Open-source FlexNIRS: A low-cost, wireless and wearable cerebral health tracker. Neuroimage. 2022 Aug 1;256:119216. doi: 10.1016/j.neuroimage.2022.119216. Epub 2022 Apr 19. PMID: 35452803.



7: Pace DF, Dalca AV, Brosch T, Geva T, Powell AJ, Weese J, Moghari MH, Golland P. Learned iterative segmentation of highly variable anatomy from limited data: Applications to whole heart segmentation for congenital heart disease. Med Image Anal. 2022 Aug;80:102469. doi: 10.1016/j.media.2022.102469. Epub 2022 May 13. PMID: 35640385.



8: DeVience SJ, Rosen MS. Homonuclear J-coupling spectroscopy using J-synchronized echo detection. J Magn Reson. 2022 Aug;341:107244. doi: 10.1016/j.jmr.2022.107244. Epub 2022 May 23. PMID: 35667308.



9: Aly AH, Khandelwal P, Aly AH, Kawashima T, Mori K, Saito Y, Hung J, Gorman JH 3rd, Pouch AM, Gorman RC, Yushkevich PA. Fully Automated 3D Segmentation and Diffeomorphic Medial Modeling of the Left Ventricle Mitral Valve Complex in Ischemic Mitral Regurgitation. Med Image Anal. 2022 Aug;80:102513. doi: 10.1016/j.media.2022.102513. Epub 2022 Jun 12. PMID: 35772323.



10: Janelidze S, Christian BT, Price J, Laymon C, Schupf N, Klunk WE, Lott I, Silverman W, Rosas HD, Zaman S, Mapstone M, Lai F, Ances BM, Handen BL, Hansson O. Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers. JAMA Neurol. 2022 Aug 1;79(8):797-807. doi: 10.1001/jamaneurol.2022.1740. PMID: 35789365; PMCID: PMC9257682.



11: Ferencik M, Mayrhofer T, Lu MT, Bittner DO, Emami H, Puchner SB, Meyersohn NM, Ivanov AV, Adami EC, Voora D, Ginsburg GS, Januzzi JL, Douglas PS, Hoffmann U. Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain: The PROMISE Trial Results. JACC Cardiovasc Imaging. 2022 Aug;15(8):1427-1438. doi: 10.1016/j.jcmg.2022.03.016. Epub 2022 May 11. PMID: 35926901; PMCID: PMC9353061.



12: Daye D, Wiggins WF, Lungren MP, Alkasab T, Kottler N, Allen B, Roth CJ, Bizzo BC, Durniak K, Brink JA, Larson DB, Dreyer KJ, Langlotz CP. Implementation of Clinical Artificial Intelligence in Radiology: Who Decides and How? Radiology. 2022 Aug 2:212151. doi: 10.1148/radiol.212151. Epub ahead of print. PMID: 35916673.



13: Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Phys Med Biol. 2022 Aug 5;67(15). doi: 10.1088/1361-6560/ac65d3. PMID: 35395649.



14: Evans SB, Blitzblau RC, Chapman CH, Chollet-Lipscomb C, Deville C, Ford E, Gibbs IC, Howell K, Peters GW, Ponce SB, Seldon C, Spector-Bagdady K, Tarbell N, Terezakis S, Vyfhius MAL, Wright J, Zietman A, Jagsi R. Restricted Access to Abortion, the Dobbs Ruling, and Radiation Oncology: Standing United Against Reproductive Injustice. Int J Radiat Oncol Biol Phys. 2022 Aug 10:S0360-3016(22)02598-6. doi: 10.1016/j.ijrobp.2022.07.1843. Epub ahead of print. PMID: 35963470.



15: Insel PS, Young CB, Aisen PS, Johnson KA, Sperling RA, Mormino EC, Donohue MC. Tau positron emission tomography in preclinical Alzheimer's disease. Brain. 2022 Aug 13:awac299. doi: 10.1093/brain/awac299. Epub ahead of print. PMID: 35962782.



16: Brown EM, Salat DH, Milberg WP, Fortier CB, McGlinchey RE. Accelerated longitudinal cortical atrophy in OEF/OIF/OND veterans with severe PTSD and the impact of comorbid TBI. Hum Brain Mapp. 2022 Aug 15;43(12):3694-3705. doi: 10.1002/hbm.25877. Epub 2022 Apr 15. PMID: 35426972; PMCID: PMC9294300.



17: Varadarajan D, Magnain C, Fogarty M, Boas DA, Fischl B, Wang H. A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images. Neuroimage. 2022 Aug 15;257:119304. doi: 10.1016/j.neuroimage.2022.119304. Epub 2022 May 11. PMID: 35568350.



18: Maffei C, Girard G, Schilling KG, Aydogan DB, Adluru N, Zhylka A, Wu Y, Mancini M, Hamamci A, Sarica A, Teillac A, Baete SH, Karimi D, Yeh FC, Yildiz ME, Gholipour A, Bihan-Poudec Y, Hiba B, Quattrone A, Quattrone A, Boshkovski T, Stikov N, Yap PT, de Luca A, Pluim J, Leemans A, Prabhakaran V, Bendlin BB, Alexander AL, Landman BA, Canales-Rodríguez EJ, Barakovic M, Rafael-Patino J, Yu T, Rensonnet G, Schiavi S, Daducci A, Pizzolato M, Fischi-Gomez E, Thiran JP, Dai G, Grisot G, Lazovski N, Puch S, Ramos M, Rodrigues P, Prčkovska V, Jones R, Lehman J, Haber SN, Yendiki A. Insights from the IronTract challenge: Optimal methods for mapping brain pathways from multi-shell diffusion MRI. Neuroimage. 2022 Aug 15;257:119327. doi: 10.1016/j.neuroimage.2022.119327. Epub 2022 May 26. PMID: 35636227; PMCID: PMC9453851.



19: Lahti J, Tuominen S, Yang Q, Pergola G, Ahmad S, Amin N, Armstrong NJ, Beiser A, Bey K, Bis JC, Boerwinkle E, Bressler J, Campbell A, Campbell H, Chen Q, Corley J, Cox SR, Davies G, De Jager PL, Derks EM, Faul JD, Fitzpatrick AL, Fohner AE, Ford I, Fornage M, Gerring Z, Grabe HJ, Grodstein F, Gudnason V, Simonsick E, Holliday EG, Joshi PK, Kajantie E, Kaprio J, Karell P, Kleineidam L, Knol MJ, Kochan NA, Kwok JB, Leber M, Lam M, Lee T, Li S, Loukola A, Luck T, Marioni RE, Mather KA, Medland S, Mirza SS, Nalls MA, Nho K, O'Donnell A, Oldmeadow C, Painter J, Pattie A, Reppermund S, Risacher SL, Rose RJ, Sadashivaiah V, Scholz M, Satizabal CL, Schofield PW, Schraut KE, Scott RJ, Simino J, Smith AV, Smith JA, Stott DJ, Surakka I, Teumer A, Thalamuthu A, Trompet S, Turner ST, van der Lee SJ, Villringer A, Völker U, Wilson RS, Wittfeld K, Vuoksimaa E, Xia R, Yaffe K, Yu L, Zare H, Zhao W, Ames D, Attia J, Bennett DA, Brodaty H, Chasman DI, Goldman AL, Hayward C, Ikram MA, Jukema JW, Kardia SLR, Lencz T, Loeffler M, Mattay VS, Palotie A, Psaty BM, Ramirez A, Ridker PM, Riedel-Heller SG, Sachdev PS, Saykin AJ, Scherer M, Schofield PR, Sidney S, Starr JM, Trollor J, Ulrich W, Wagner M, Weir DR, Wilson JF, Wright MJ, Weinberger DR, Debette S, Eriksson JG, Mosley TH Jr, Launer LJ, van Duijn CM, Deary IJ, Seshadri S, Räikkönen K. Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Mol Psychiatry. 2022 Aug 16. doi: 10.1038/s41380-022-01710-8. Epub ahead of print. PMID: 35974141.



20: Mikail N, Rossi A, Bengs S, Haider A, Stähli BE, Portmann A, Imperiale A, Treyer V, Meisel A, Pazhenkottil AP, Messerli M, Regitz-Zagrosek V, Kaufmann PA, Buechel RR, Gebhard C. Imaging of heart disease in women: review and case presentation. Eur J Nucl Med Mol Imaging. 2022 Aug 17. doi: 10.1007/s00259-022-05914-6. Epub ahead of print. PMID: 35974185.



21: An L, Chen J, Chen P, Zhang C, He T, Chen C, Zhou JH, Yeo BTT; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle Study of Aging. Goal-specific brain MRI harmonization. Neuroimage. 2022 Aug 17;263:119570. doi: 10.1016/j.neuroimage.2022.119570. Epub ahead of print. PMID: 35987490.



22: Lankinen K, Ahlfors SP, Mamashli F, Blazejewska AI, Raij T, Turpin T, Polimeni JR, Ahveninen J. Cortical depth profiles of auditory and visual 7 T functional MRI responses in human superior temporal areas. Hum Brain Mapp. 2022 Aug 18. doi: 10.1002/hbm.26046. Epub ahead of print. PMID: 35980015.



23: Seitz-Holland J, Wojcik JD, Cetin-Karayumak S, Lyall AE, Pasternak O, Rathi Y, Vangel M, Pearlson G, Tamminga C, Sweeney JA, Clementz BA, Schretlen DA, Viher PV, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan RW, Szeszko PR, Malhotra AK, Kelly S, Shenton ME, Keshavan MS, Mesholam-Gately RI, Kubicki M. Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study. Mol Psychiatry. 2022 Aug 18. doi: 10.1038/s41380-022-01731-3. Epub ahead of print. PMID: 35982257.



24: Nepal P, Bagga B, Feng L, Chandarana H. Respiratory Motion Management in Abdominal MRI: Radiology In Training. Radiology. 2022 Aug 23:220448. doi: 10.1148/radiol.220448. Epub ahead of print. PMID: 35997609.



25: Hassan MZO, Awadalla M, Tan TC, Scherrer-Crosbie M, Bakar RB, Drobni ZD, Zarif A, Gilman HK, Supraja S, Nikolaidou S, Zhang L, Zlotoff DA, Hickey SB, Patel SA, Januzzi JL, Keane F, Passeri JJ, Neilan TG, MacDonald SM, Jimenez RB. Serial Measurement of Global Longitudinal Strain among Women with Breast Cancer treated with Proton Radiation Therapy: A Prospective Trial for 70 Patients. Int J Radiat Oncol Biol Phys. 2022 Aug 23:S0360-3016(22)03141-8. doi: 10.1016/j.ijrobp.2022.08.036. Epub ahead of print. PMID: 36028065.



26: Jungilligens J, Paredes-Echeverri S, Popkirov S, Barrett LF, Perez DL. A new science of emotion: implications for functional neurological disorder. Brain. 2022 Aug 27;145(8):2648-2663. doi: 10.1093/brain/awac204. PMID: 35653495.



27: Li X, Marschall TA, Yang K, Liu B. Calculation of scan length and size- specific dose at longitudinal positions of body CT scans using dose equilibrium function. Med Phys. 2022 Aug 30. doi: 10.1002/mp.15959. Epub ahead of print. PMID: 36040318.



28: Abraham P, Balthazar P, Reid NJ, Flores EJ, Narayan AK. The Digital Divide in Radiology: Computer Use for Health Care-related Tasks and Breast Cancer Screening. Radiology. 2022 Aug 30:220796. doi: 10.1148/radiol.220796. Epub ahead of print. PMID: 36040332.



29: Kanne JP, Little BP, Schulte JJ, Haramati A, Haramati LB. Long-Term Lung Abnormalities Associated with COVID-19 Pneumonia. Radiology. 2022 Aug 30:221806. doi: 10.1148/radiol.221806. Epub ahead of print. PMID: 36040336; PMCID: PMC9462591.



30: Stoustrup P, Resnick CM, Abramowicz S, Pedersen TK, Michelotti A, Küseler A, Koos B, Verna C, Nordal EB, Granquist EJ, Halbig JM, Kristensen KD, Kaban LB, Arvidsson LZ, Spiegel L, Stoll ML, Lerman MA, Glerup M, Defabianis P, Frid P, Alstergren P, Cron RQ, Ringold S, Nørholt SE, Peltomaki T, Larheim TA, Herlin T, Peacock ZS, Kellenberger CJ, Twilt M; Temporomandibular Joint Juvenile Arthritis Working group (TMJaw). Management of orofacial manifestations of juvenile idiopathic arthritis: Interdisciplinary consensus-based recommendations. Arthritis Rheumatol. 2022 Aug 30. doi: 10.1002/art.42338. Epub ahead of print. PMID: 36041065.



31: Dickey CW, Verzhbinsky IA, Jiang X, Rosen BQ, Kajfez S, Eskandar EN, Gonzalez-Martinez J, Cash SS, Halgren E. Cortical ripples during NREM sleep and waking in humans. J Neurosci. 2022 Aug 30:JN-RM-0742-22. doi: 10.1523/JNEUROSCI.0742-22.2022. Epub ahead of print. PMID: 36041852.



32: Ioakeim-Ioannidou M, Giantsoudi D, Niemierko A, Sethi R, Kim DW, Yock TI, Tarbell NJ, Simeone FJ, MacDonald SM. Effects of Proton Craniospinal Radiation on Vertebral Body Growth Retardation in Children. Int J Radiat Oncol Biol Phys. 2022 Aug 30:S0360-3016(22)03212-6. doi: 10.1016/j.ijrobp.2022.08.055. Epub ahead of print. PMID: 36055432.



33: Howard AF, Cottaar M, Drakesmith M, Fan Q, Huang SY, Jones DK, Lange FJ, Mollink J, Rudrapatna SU, Tian Q, Miller KL, Jbabdi S. Estimating axial diffusivity in the NODDI model. Neuroimage. 2022 Nov 15;262:119535. doi: 10.1016/j.neuroimage.2022.119535. Epub 2022 Aug 2. PMID: 35931306.



34: Wu J, Li J, Eickhoff SB, Hoffstaedter F, Hanke M, Yeo BTT, Genon S. Cross- cohort replicability and generalizability of connectivity-based psychometric prediction patterns. Neuroimage. 2022 Nov 15;262:119569. doi: 10.1016/j.neuroimage.2022.119569. Epub 2022 Aug 17. PMID: 35985618.