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The CADRC is a collaboration between Case Western Reserve University ~ Cleveland Clinic ~ Louis Stokes VA Medical Center ~ MetroHealth ~ University Hospitals

CADRC Summer E-Newsletter l Issue 5

Neuroimaging Core Spotlight

Dr. Lowe Spotlight Interview

Tell us about yourself and how you are involved with the Cleveland Alzheimer’s Disease Research Center (CADRC).

I am an experimental particle physicist by training who trained in magnetic resonance imaging (MRI) during a postdoctoral fellowship at the University of Wisconsin. I’m a Professor of Radiology at the Cleveland Clinic Lerner College of Medicine and the Director of High Field MRI at Cleveland Clinic. My lab specializes in brain function and structure using MRI and developing methodologies for investigating neurologic and neuropsychiatric diseases. I am the NeuroImaging Core Leader of the CADRC. Dr. Frank DiFilippo, a PET-imaging physicist is the Co-Leader of the core, and together we make most of the operational decisions with an excellent team of radiologists and physicists from CWRU and CCF. The Core’s objective is to provide high-level imaging expertise as cutting edge data to Alzheimer’s Disease (AD) and Alzheimer’s Disease Research Center (ADRC) researchers, both regionally and nationally.

What are your main activities and goals as they relate to brain health?

My main focus is to develop imaging based biomarkers for the diagnosis and development of therapies for aging brain related diseases and AD. This is a huge need in the AD field, just because the therapies that are available are limited and not as effective as we would like. Part of the problem is the lack of a set of agreed upon biomarkers for disease progression in AD. So, my research efforts focus on developing MRI-based measures that can detect cognitive decline in the aging brain, hopefully before they become serious enough to impact quality of life.

Click here to access Neuroimaging Core FAQs.

Click here to read the full interview

Are you Interested in Participating in Research at the CADRC?

Researchers from Case Western Reserve University, Cleveland Clinic, MetroHealth, University Hospitals and the Louis Stokes Cleveland VA Medical Center have joined together to form the Cleveland Alzheimer's Disease Research Center (CADRC). The CADRC is one of 33 centers funded by the National Institutes on Aging. The center aims to study the different forms of dementia in the hope that learning more about the disease can lead to new forms of treating and eventually curing Alzheimer's and related disorders. Volunteers are critical to the research process and the center studies both people with Alzheimer’s disease and healthy individuals who are at risk for developing dementia. Signs of memory or thinking issues are not required to participate.

If you would like to be contacted about research opportunities at the CADRC for yourself or someone you know, please click the link below to fill out the form or contact us at

1-888-311-ADRC (2372).

Click here to complete the form

Developmental Project Awardee Spotlight

Aaron Burberry, PhD Spotlight Interview

Tell us about yourself and how you are involved with the Cleveland Alzheimer’s Disease Research Center (CADRC).

In 2021, I joined the faculty at Case Western Reserve University as an Assistant Professor. As a pre-doctoral student, I studied a microbial sensing pathway that acts in our gut to restrict the development of Crohn’s disease. Now, I am leveraging funding from the CADRC to uncover which components of the gut microbiome tip the balance between a healthy brain and a brain engulfed by inflammation.

What are your main activities and goals as they relate to brain health?

One of the greatest mysteries in our society is why some people develop neurodegenerative diseases such as Alzheimer’s (AD) and others do not. The main goal of my laboratory is to identify factors from our environment that affect immune cell support of neuronal health. My hope is that this knowledge will ultimately lead to new immunological and microbial therapeutic targets and help to direct people at risk of dementia towards clinical trials with the greatest chance of personal benefit.

Click here to read the full interview

Minority Advisory Board Spotlight

Rev. Ruby Holland Spotlight Interview

Tell us a little about yourself. What's your favorite pastime?

I was born and raised in several sections of the Cleveland area. My favorite pastime would have to be fishing down at the Lake Erie Pier. I also enjoy walking and hiking with my best friend, my husband, Dr. Vincent Holland, and playing with our three wonderful cats.

Why is the topic of Alzheimer’s Disease important to you personally?

My mother is now 104 years of age and has better memory than some young adults in my circle of acquaintances. Additionally, as a Volunteer Chaplain for a senior citizens apartment building, I take their memory/mental care and needs very seriously; therefore I see this topic as even more relevant for me today.

Tell us why you volunteer for the Minority Advisory Board? How long have you been involved?

I met Edna Fuentes-Casiano staff of the CADRC and Minority Board Member. She felt that I would make a great board member and invited me to attend my first meeting in May 2022. I truly believe that God’s hand is upon this collaboration.

Minority Men's Health Fair:

In an effort to bring awareness to the Cleveland Alzheimer's Disease Research Center and engage the community in CADRC research, we participated in the Minority Men's Health Fair at MetroHealth on April 28, 2022. The Minority Men's Health Fair is a long-standing event for health screenings and education. Dr. Charles Modlin (founder and director), created the free health fair more than 17 years ago to address disproportionate disease rates in African American men.

Memory Sunday:

On Sunday, June 12, 2022 faith-based communities were joined virtually across the country as an initiative of The National Brain Health Center for African Americans, a program of The Balm in Gilead.

Dr. Dylan Wint (Director, NV Cleveland Clinic Lou Ruvo Center for Brain Health) and Dr. Alan Lerner (Co-Director, Cleveland Alzheimer's Disease Research Center's Clinical Core) spoke about ways to reduce the risk of developing dementia and ways to support individuals living with Alzheimer's disease and their caregivers.

We accomplished the goal of bringing this important program to Cleveland for a second year in a row. We look forward to building a coalition of community leaders and organizations to fully embrace the role of the church in brain health, awareness, education and participation in research.

Click here to access past CADRC webinar recordings

Cleveland Clinic Stephanie Tubbs Jones Health Center Summer Community Resource Event:

The CADRC participated in the Cleveland Clinic Stephanie Tubbs Jones Health Center summer community resource event which was held on Saturday, July 9^th . The event components and activities consisted of health presentations, health screenings, health resource tables, safety prevention demonstrations, legal aid services, food trucks, a live DJ and more!

Walk to End Alzheimer's

Held annually in more than 600 communities nationwide, the Alzheimer's Association Walk to End Alzheimer's is the world's largest event to raise awareness and funds for Alzheimer's care, support and research.

Please join the CADRC Team and walk with us on Sunday, October 2nd at the Cleveland Metroparks Zoo. The Cleveland Walk is a family friendly event! After the Walk, you can stay at the Zoo as long as you like. All donations will support the Alzheimer’s Association’s many programs and services.

For more information about the CADRC Walk Team and additional locations where we will have information tables, visit clevelandadrc.org.

Click here to join and donate to the CADRC walk team

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