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December 2024 | Weekly Digest robot


Antibody Therapy Solutions

Dear ACROBio systems,


Check out our personalized, featured highlights in this week's digest, including:


Keep reading to learn more!

FEATURED PRODUCT | ADC Development

Tools for ADC PK Analysis——Anti-payload antibodies

For ADCs, evaluations of DAR and PK/PD studies are vital due to complex matrices. Characterizing each component of ADCs requires following distinct gold standards, which involve the use of analytical methods like ELISAs and LC-MS. Our anti-payload antibodies target DM-1, DXD, SN38, MMAE, Eribulin, and more, ideal for ELISA assays in your ADC PK studies!

Immobilized Mouse Anti-DXD&Exatecan Antibody, Mouse IgG1, mAb (Cat. No. DXD-M684) at 1 μg/mL, add Trastuzumab deruxtecan in the 50% Human serum and then add Biotinylated Human Her2, His, Avitag, premium grade (Cat. No. HE2-H82E2) at 0.5 μg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (Routinely tested).

Discover More!

FEATURED PRODUCT | Autoimmune diseases

Potential targets for Systemic Lupus Erythematosus treatment

Systemic Lupus Erythematosus (SLE) is a multifaceted autoimmune disease where B cell overactivity leading to immune imbalance. Targeting immune checkpoints, such as OX40 L, BLyS, and CD40L, is key to developing novel therapies. These targets shows promise in managing SLE and preventing organ damage.

Featured Products:

  • OX40L: Active trimer structure verified by SEC-MALS
  • BAFF: Binding activity validated
  • CD40L: Cover various proteins & stable cell line
Discover SLE Targets Today

FEATURED PRODUCT| ADC development

Protease Solutions Enhancing Payload Delivery in ADCs

In the domain of Antibody-Drug Conjugates (ADCs), the linker is crucial for stability and lysosomal processing. Cleavable-linker ADCs rely on proteases such as Cathepsin B/L, MMPs, and β-Glucuronidase for efficient drug release. ACROBiosystems offers innovated Cathepsin B/L and MMPs protein products tailored for precise linker cleavage and optimized payload delivery.

Explore More About Our ADC Solutions


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