The RNA Transcript, August 17, 2020
Rackham Professional Development DEI Certificate
The Rackham Graduate School is committed to enhancing the development and training offerings related to diversity, equity, and inclusion for all University of Michigan graduate students and postdoctoral fellows and is now offering a Professional Development DEI Certificate. This program is designed to prepare participants to work in a diverse environment while fostering a climate of inclusivity. Application deadline: September 11
Thursday, August 20, 2020, noon–1:00 pm CST | Taubman Institute, Taubman Technology Talks webinar

Beyond Just Pictures: Multi-scale, Quantitative Imaging
Gary Luker, M.D., will present several different technologies to meet demands of imaging studies and computational approaches to extract quantitative imaging data from imaging studies.
Wednesday, August 26, 2020, 4:00–5:00 pm |

“Image-based spatial genomics
and transcriptomics”
“RNA decay deficits cause neurodegeneration in ALS/FTD”   

Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are highlights from the last four weeks.
Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies Yuan, Z., Zhu, H., Zeng, P. et al., Nat Commun 11, 3861 (2020).

"We present a probabilistic Mendelian randomization (MR) method, PMR-Egger, for TWAS applications. We illustrate the benefits of PMR-Egger in applications to 39 diseases and complex traits obtained from three GWASs including the UK Biobank."
Small Molecules Restore Telomeres in Patient Stem Cells

Genetic defects in telomere maintenance result in stem cell exhaustion and a spectrum of telomere biology diseases. Systemic treatments beyond organ transplantation are lacking for these diseases. Nagpal and colleagues identified small molecules that restore telomere maintenance in patient-derived stem cells, offering a promising therapy for telomere biology diseases.