The RNA Transcript, December 20, 2021
Your next RNA Transcript will arrive in your email box, Monday, January 3rd, 2022!
|
|
We wish to inform you that as of the new year, Elisabeth Paymal, the Center's communication officer, will be moving to a new position within Michigan Medicine. We wish Elisabeth all the best for this next stage of her career.
"On behalf of the Center for RNA Biomedicine, we thank Elisabeth for the tremendous work she has done over the past two years in building our communications, particularly the weekly RNA Transcript and the annual RNA Translated magazine. Her efforts have made a significant difference and enhanced the Center's profile, for which we will always be grateful."
—Nils Walter and Mats Ljungman, co-directors of the Center for RNA Biomedicine
"I take this opportunity to express again my gratitude to all of you who have been so engaged and supportive of the Center's communications! Thanks to your contributions, the Center's visibility has much increased and RNA research is looking at a bright future. It has been a wonderful experience to learn about your amazing research, and a pleasure to get to know some of you more personally."
—Elisabeth Paymal
|
|
Happy Solstice!
It only gets brighter from here.
The first day of winter in the Northern Hemisphere is marked by the winter solstice, which, this year, occurs on Tuesday, December 21, 2021, at 10:59 A.M. EST.
The winter solstice is the day with the fewest hours of sunlight in the whole year, making it the “shortest day” of the year. Thankfully, after we reach the winter solstice, the days begin to once again grow longer and longer until we reach the summer solstice—the first day of summer and the longest day of the year.
Photo: Sunset over the Huron River seen from Fuller Road, Ann Arbor (credit: Elisabeth Paymal)
|
|
Monday–Thursday, January 3-6, 2022, Hilton Bayfront St. Petersburg, FL
6th Meeting on Regulating with RNA in Bacteria and Archaea
|
|
University of Cambridge, UK
Analisa DiFeo, Pathology and Ob/Gyn, Medical School, University of Michigan
|
|
For press releases and blog articles about your upcoming top journal publications, please
|
|
Our members' publications are available through Altmetric. Sept queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Please make sure to have at least one of these keywords in your title. Below are recent highlights.
|
|
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
M. Zafferani, C. Haddad , Le Luo , J. Davila-Calderon, Liang-Yuan Chiu, C. Shema Mugisha, A. Monaghanan, D. Kennedy, J. Yesselman, R. Gifford, A. Tai, S. Kutluay, Mei-Ling Li, G. Brewer, B. Tolbert and A. E. Hargrove, Science Advances, 26 Nov 2021, Vol 7, Issue 48, DOI: 10.1126/sciadv.abl6096
Abstract: ... Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication through targeting of conserved structured elements within the viral 5′-end. Nuclear magnetic resonance–based structural studies revealed specific amiloride interactions with stem loops containing bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Amilorides represent the first antiviral small molecules that target RNA structures within the 5′ untranslated regions and proximal region of the CoV genomes. These molecules will serve as chemical probes to further understand CoV RNA biology and can pave the way for the development of specific CoV RNA–targeted antivirals.
|
|
TissueNexus: a database of human tissue functional gene networks built with a large compendium of curated RNA-seq data
Abstract: Mapping gene interactions within tissues/cell types plays a crucial role in understanding the genetic basis of human physiology and disease. Tissue functional gene networks (FGNs) are essential models for mapping complex gene interactions. We present TissueNexus, a database of 49 human tissue/cell line FGNs constructed by integrating heterogeneous genomic data. ...
|
|
To share your news
and comments, please
|
|
|
|
|
|
|
|
