The RNA Transcript, January 4, 2021

Only a couple of weeks after defending her Ph.D. thesis in November, Sarah Owen, a graduate student in Chemical Engineering in Dr. Sunitha Nagrath’s lab, landed her dream job. “It all went very fast,” she explained, “I had a seven-hour zoom interview on Thursday, and they offered me the job the following Monday!”

In January 2021, Owen will join Seagen, a biomedical company that seeks to improve the lives of people with cancer through innovative targeted therapies. As a Process Scientist, she will develop novel ways to test and characterize drug compounds after their R&D phase, and before clinical trials.
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Tuesday, January 5, 3:00 pm EST | Harvard Medical School, Initiative for RNA Medicine Seminar
 ZOOM, Password: 759932
 
“Role and mechanism of action of miRNAs in skeletal development and dysplasias”
Tatsuya Kobayashi, M.D., Ph.D., Assistant Professor of Medicine, Massachusetts General Hospital, Harvard Medical School
Wednesday–Friday, January 6–8, 2021 | Intersections Science Fellows Symposium
This multi-institutional symposium will showcase the work of mid- to late stage postdocs in biomedical science on January 6-8th, 2021, virtually. This exciting symposium aims to showcase the science of outstanding postdocs specially those who are from backgrounds historically underrepresented in academia to advance diversity, equity and inclusion in academic science. 
 
For more information, please visit our website and follow us on Twitter @InterSciFellows.
For any questions, please contact: info@intersectionssciencefellows.com
Wednesday, January 13, 4:00–5:00 pm EST | RNA Collaborative Seminar Series, NCI RNA Biology Initiative hosting
ZOOM TBA here

“Ribosome collisions and sites of quality control revealed by ribosome profiling”

“CRISPR screening to identify biologically important microRNA targets”

Monday, January 25, 4:00–5:00 pm EST | U-M Center for RNA Biomedicine, RNA Innovation Seminar Series
ZOOM REGISTRATION REQUIRED (please register early)
 
Title TBA
5th RNA SYMPOSIUM SCHEDULE

Thursday, March 25, 2021 
11:00-11:05 / Welcome
11:05-12:00 / Keynote 1: Tracy Johnson, Ph.D., University of California – Los Angeles (RNA Splicing)
12:00-12:10 / short break
12:10-1:05 / Keynote 2: Kevin Weeks, Ph.D., University of North Carolina (RNA Structure in vivo)
1:05-1:35 / Data Blitz (part 1)
1:35-2:30 / Keynote 3: Christopher Lima, Ph.D., Memorial Sloan-Kettering (RNA degradation)
2:30-2:30 / Brief close

Friday, March 26, 2021
11:00-11:05 / Welcome
11:05-12:00 / Keynote 4: Brenda Bass, Ph.D., University of Utah (RNA editing & silencing)
12:00-12:10 / short break
12:10-1:05 / Keynote 5: Feng Zhang, Ph.D., MIT (CRISPR applications)
1:05-1:35 / Data Blitz (part 2)
1:35-2:25 / Panel
2:25-2:30 / Closing
 
Contact Elisabeth Paymal for press releases and blog articles of your upcoming publications. MORE INFORMATION

Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below is a recent highlight.
High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction, Stefan, M.A., Velazquez, G.M. & Garcia, G.A. in Mycobacterium tuberculosisSci Rep 10, 21309 (2020). https://doi.org/10.1038/s41598-020-78269-3

Significance
We expect that the development of a new and improved anti-TB compound with a novel mechanism of action will relieve the burden of resistance. This CarD FP assay is amenable to HTS and is an enabling tool for future novel therapeutic discovery.

Key Points
  • An innovative digital assay technology enables rapid, point-of-care measurement of multiple protein biomarkers in blood.
  • Continuous monitoring of protein blood biomarker profiles is demonstrated for critically ill human patients with a digital assay.

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