The RNA Transcript, July 20, 2020
The Michigan League for Public Policy ( MLPP )

For 21 days, do one action to further your understanding of power, privilege, supremacy, oppression, and equity.
The University of Michigan Center for RNA Biomedicine regroups over 150 faculty members and their labs across seven Schools and Colleges on the Ann Arbor campus. We're pleased to feature these outstanding scientists and colleagues in our weekly news.
Assistant Professor, Pathology and Ob/Gyn, Michigan Medicine
Wednesday, July 29, 2020, 4:00–5:00 pm | RNA Collaborative Seminar Series

“Prospects for hyper-individualized RNA medicines”

“A specialized post-transcriptional program in chemoresistant, quiescent cancer cells”

Moderator: Frank Slack, Ph.D. 

September 23–25, 2020

Over 35 RNA scientists from Canada, the US and Europe, come together in this two-day forum.
Abstract submission deadline: August 1st   - Registration deadline:  September 1st

Our members' publications are now available through Altmetric. Six queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are the highlights from the last four weeks.
Coupling of translation quality control and mRNA targeting to stress granules

Using single mRNA imaging, we discovered ribosomes stall on some mRNAs during arsenite stress, and the release of transcripts from stalled ribosomes for their partitioning into stress granules requires the activities of VCP, components of the ribosome-associated quality control (RQC) complex, and the proteasome. This is an unexpected contribution of the RQC system in releasing mRNAs from translation under stress, thus identifying a new type of stress-activated RQC (saRQC) distinct from canonical RQC pathways in mRNA substrates, cellular context, and mRNA fate.
Next-generation RNA Sequencing–based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms
Stephanie L. Skala, Xiaoming Wang, Yuping Zhang, Rahul Mannan, Lisha Wang, Sathiya P. Narayanan, Pankaj Vats, Fengyun Su, Jin Chen, Xuhong Cao, Javed Siddiqui, Pedram Argani, Marcin P. Cieslik, Thomas J. Giordano, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Rohit Mehra, 0302-2838/© 2020 European Association of Urology,  

Conclusions: We demonstrate a pipeline for the identification and validation of RCC subtype– specific biomarkers that can aid in the confirmation of cell of origin and may facilitate accurate classification and diagnosis of renal tumors.