The RNA Transcript, March 29, 2021
March 25 and 26, we hosted our 5th Annual Symposium
titled “Processing RNA.”
With over 550 participants, this two-day symposium virtually gathered the vibrant RNA research community from the University of Michigan (U-M), the US, and around the world.

The symposium opened with remarks by Nils Walter, co-director of the U-M Center for RNA Biomedicine, who reminded the attendees of the importance of RNA research for society, as demonstrated by the COVID-19 RNA vaccine. Mats Ljungman, co-director of the U-M Center for RNA Biomedicine, emceed day 2.

Five distinguished keynote speakers presented on various RNA processes: Brenda Bass, Ph.D., University of Utah; Tracy Johnson, Ph.D., UCLA; Christopher Lima, Ph.D., Sloan Kettering Institute; Kevin Weeks, Ph.D., University of North Carolina; and Feng Zhang, Ph.D., MIT.

Six U-M junior and early career scientists presented their research in data blitzes: Adrien Chauvier, Ph.D., Postdoc and Research Assistant; Daniel Peltier, M.D., Ph.D., Clinical Lecturer; Meredith Purchal, Graduate Student; Cathy Smith, Graduate Student; Shannon Wright, Graduate Student; and Yan Zhang, Ph.D., Assistant Professor.

The panel discussion also provided many inspiring recommendations to trainees and mentors, from life/work balance and time management, to networking, and sharing scientific passion with one's community. These will be summarized in the next issue of The RNA Transcript.

The Michigan Science Writers, a student organization dedicated to improving public understanding of science, graciously blogged about the event. READ THE BLOGS

The data blitzes were co-sponsored by Lexogen.
This event was supported by the University of Michigan Biosciences Initiative.

Please respond to the symposium FEEDBACK SURVEY.

Together, we can do so much.
Thank you all for making this symposium such a success!
Bru-Seq Lab Scientist
The Bru-Seq Lab and the SMART Center are the two core facilities that are affiliated with the Center for RNA Biomedicine.

"In the Bru-Seq Ljungman Lab, RNA features predominantly as we developed the Bru-seq suite of techniques almost 20 years ago. Bru-seq is a next generation sequencing technique that uses nascent RNA to assess RNA transcription, turnover, enhancers, splicing, as well as other RNA processes. We work together with researchers all over the world on their Bru-seq projects as well as with major pharmaceutical companies. We are also a part of the ENCODE project as a mapping center."

Monday, March 29, 3:00 pm ET | U-M Biointerfaces, Bionic Career Chat Series

Eric Meshot, Ph.D., Lawrence Livermore National Laboratory
Tuesday, March 30, 3:00 pm ET | U-M, Human Genetics, Medical School

Genetic short course:
"Dissecting Transcriptional Dynamics in Development One Burst at a Time"
Hernan Garcia, Ph.D., Departments of Genetics, Genomics, & Development and Physics, University of California, Berkeley
Monday, April 5, 4:00 pm ET | U-M Center for RNA Biomedicine, RNA Innovation Seminar Series

“Direct binding of ESRP1 to regulated transcripts is required for position-dependent splicing regulation”
Natoya Peart, Ph.D., Postdoctoral Researcher – Carstens Lab/Lynch Lab, Department of Medicine/Department of Biochemistry and Molecular Biophysics, University of Pennsylvania
Contact Elisabeth Paymal for press releases and blog articles of your upcoming top journal publications.

Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are recent highlights.
Single-Molecule Investigation of Cooperativity within the Glycine Tandem Riboswitch

Abstract: Riboswitches are genetic regulatory elements located in the 5’ untranslated region of bacterial messenger RNAs (mRNAs). Riboswitches contains two RNA domains that function in concert to regulate gene expression levels in response to changing cellular conditions. Tandem riboswitches are particularly interesting because they can have more sophisticated mechanisms for gene regulation to respond to a broader range of conditions. However, many of the mechanisms they utilize for gene regulation remain unclear....
What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics. Juhlin, C.C., Bertherat, J., Giordano, T.J. et al. Endocr Pathol (2021).

Abstract: We herein review the histological, genetic, and epigenetic landscapes of benign and malignant adrenal cortical neoplasia from a modern surgical endocrine pathology perspective and highlight key mechanisms of value for diagnostic and prognostic purposes.
For Fun
RNA was discovered in.... (See the answer next week!)
"Of our symposium five keynote speakers, which scientist is most likely to talk about RNA Splicing?"

ANSWER: March 25, Tracy Johnson, Ph.D., UCLA, talked about “RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene expression.” Abstract here.
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