The RNA Transcript, November 30, 2020 |
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Thank you to all the healthcare
and essential workers!
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Associate Professor
Department of Computational Medicine & Bioinformatics
Department of Human Genetics
We study the effects of genetic variation on chromatin architecture and transcriptional regulation at single-cell resolution. Our research group uses an integrative approach in the general fields of computational biology and functional genomics. The major goal of the lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome, with a focus on complex metabolic diseases including diabetes and related traits.
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“RAS signaling regulates the noncoding transcriptome”
“How do noncoding RNAs contribute to inflammation?”
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Noon, Thursday, December 3, 12:00 pm | U-M Life Sciences Institute Seminar Series
Astrid D. Haase, M.D., Ph.D. Stadtman Tenure-Track Investigator
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Hosted by: Vivian Cheung, M.D.
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Registration and abstract submission for the 2020 Bay Area RNA Conference:
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Friday December 4, 2020, 3:00 pm EST | U-M The Department of Medicinal Chemistry
ZOOM, Meeting ID: 966 9548 1212
“Inhibition of Nucleotide and One-Carbon Metabolism for the Treatment of Cancer”
Christine Cuthbertson, mentor: Dr. Nouri Neamati
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Monday, December 7, 4:00–5:00 pm EST | U-M Center for RNA Biomedicine RNA Innovation Seminar Series
"RNA at the epicenter of cell and developmental biology"
John Mattick, Ph.D., Professor of RNA Biology, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
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Tuesday, December 8, 2020, 9:00 am | U-M Chemistry, Dissertation Defense
"Mechanism of Transcription and Translation Regulation by Riboswitches in Bacteria"
Shiba Dandpat, advisor: Nils G. Walter
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Thursday, December 10, 2020, 1:10–4:45 pm | U-M Complex Systems Presents: A Nobel Symposium (INFO)
University of Michigan faculty will discuss the work, impact, and personalities of the 2020 Nobel Laureates
1:15–1:50: Nils G. Walter, co-director of the Center for RNA Biomedicine, will discuss the Chemistry Prize, CRISPR and RNA impact on biomedicine.
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Thursday, December 10, 2020, 2:00 pm | U-M Chemistry, Dissertation Defense
“To find and to form: Strategies for intracellular molecular target search and higher-order assembly”
Ameya Jalihal, advisor: Nils G. Walter
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January 6–8, 2021 | Intersections Science Fellows Symposium
This multi-institutional symposium will showcase the work of mid- to late stage postdocs in biomedical science on January 6-8th, 2021, virtually. This exciting symposium aims to showcase the science of outstanding postdocs specially those who are from backgrounds historically underrepresented in academia to advance diversity, equity and inclusion in academic science.
Applications consist of a research statement (1 page), diversity statement (1 page), and a CV, by the December 1st, 2020 (11:59PM EST) deadline.
For more information, please visit our website and follow us on Twitter @InterSciFellows.
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Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below is a recent highlight.
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Broad noncoding transcription suggests genome surveillance by RNA polymerase V
Masayuki Tsuzuki, Shriya Sethuraman, Adriana N. Coke, M. Hafiz Rothi, Alan P. Boyle, and Andrzej T. Wierzbicki, Proceedings of the National Academy of Sciences, first published November 16, 2020; https://doi.org/10.1073/pnas.2014419117
Significance
Eukaryotic genomes are pervasively transcribed, yet most transcribed sequences lack conservation or known biological functions. We show that a specialized plant-specific RNA polymerase V broadly transcribes the Arabidopsis genome. We propose a model where Pol V transcription surveils the genome and is required to recognize and repress newly inserted or reactivated transposons. Our results indicate that pervasive transcription of nonconserved sequences may serve an essential role in maintenance of genome integrity.
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Classification and segmentation of single-molecule fluorescence time traces with deep learning, Jieming Li, Leyou Zhang, Alexander Johnson-Buck and Nils G. Walter, Nature Communications, (2020)11:5833, https://doi.org/10.1038/s41467-020-19673-1
The observation of single biomolecules in real-time is crucial for our understanding of the cellular biology that is assembled from these molecules, be they DNA, RNA or protein. The recent development of an array of tools and techniques for single-molecule analysis allows studies at an extremely small scale (nanometers, or 10-9 meters) over short periods of time (from a few milliseconds to a seconds).
However, until now, most such observations required tedious and time-consuming manual data processing of thousands of single molecules. A team of University of Michigan (U-M) Department of Chemistry and Department of Physics scientists, spearheaded by graduate students Jieming Li, now Ph.D. in Chemistry, and Leyou Zhang, now Ph.D. in Physics, developed a deep learning algorithm to analyze data emerging from a single molecule microscope. The results from this collaboration are published in Nature Communications (November 2020).
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