The RNA Transcript, October 19, 2020
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Once again, the Nobel Prize recognizes the most revolutionary and innovative scientific discoveries that have the highest potential to transform humankind. Drs. Jennifer Doudna and Emmanuelle Charpentier, both biochemists, were awarded the Nobel Prize in Chemistry 2020 “for the development of a method for genome editing,” known as RNA-guided CRISPR.

At the University of Michigan, many members of the Center for RNA Biomedicine are actively studying or using CRISPR technology and expanding its applications.


World CRISPR Day brings together the entire genome engineering community to discuss how we can safely enable discovery, therapeutics, and practical applications. This unique digital event features an incredible cast of talented genome engineers, scientists, and key opinion leaders. They'll engage the research community with insights, practical methods to apply in the lab, and a vision for the future of CRISPR.

Did you miss it?
RNA Translated, our annual magazine and brief report is out!

We are pleased to share with you RNA Translated, the U-M Center for RNA Biomedicine's annual magazine and brief report. Read about the impact of collaborative RNA research. Special thanks to all our contributors!

Featured researcher
Arthur F. Thurnau Professor and Sally L. Allen Collegiate Professor of Ecology
& Evolutionary Biology and Molecular, Cellular & Developmental Biology
Wittkopp's research aims to understand the genetic, molecular, and evolutionary mechanisms responsible for phenotypic differences within and between species. Changes in gene expression are a major source of these differences, and we study the genetic changes responsible for differences in gene expression, including understanding how regulatory networks are impacted to alter expression.
Watch an animation that shows yeast cells expressing a Yellow Fluorescent Protein, which we use as a read-out of gene expression in living cells.
October 19, 4:00–5:00 pm | U-M Center for RNA Biomedicine
UM RNA Innovation Seminar Series

Gene Yeo, Ph.D., Professor, Dept of Cellular and Molecular Medicine, University of California - San Diego
"Systematic discovery of molecular and cellular functions of RNA binding proteins"

Wednesday, October 21, 4:00–5:00 pm EDT | RNA Collaborative Seminar Series, hosted by The University of Pennsylvania, Penn RNA Group


Kathy Fange Liu, Ph.D. "RNA species dance to the beat of modifications"
Yoseph Barash, Ph.D. "Splicing quantification from RNASeq - How to get the signal out of the noise?"

Friday, Saturday, October 23–24 | Rustbelt RNA Meeting
Keynote speaker: Professor Rachel Green, Johns Hopkins University
October 26, 9:00–10:00 am | U-M Center for RNA Biomedicine
UM RNA Innovation Seminar Series

Professor, The University of Western Australia Centre for Medical Research
"Regulation of the mitochondrial transcriptome in health and disease"

Friday, December 4 | 2020 Bay Area RNA Conference
Registration and abstract submission for the 2020 Bay Area RNA Conference are now open: https://barc.ucsf.edu

Once you are registered, you may submit speaker/poster presentation abstracts on your profile page, ie “Submit a New Presentation.” Deadline for abstract submissions: November 01.
 
Contact Elisabeth Paymal for press releases and blog articles of your upcoming publications. MORE INFORMATION

Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are recent highlights.
Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
Wu, X., Niculite, C.M., Preda, M.B. et al. Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORSNat Commun 11, 4755 (2020). https://doi.org/10.1038/s41467-020-18411-x

We hereby provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. 
Translational control in aging and neurodegeneration
Geena Skariah, Peter K. Todd, 20 September 2020, Wires RNA Wiley, https://doi.org/10.1002/wrna.1628

These new findings point to nodes in posttranscriptional gene regulation that both contribute to aging and offer targets for therapy.
(Equivalent to a Faculty level Associate Professor or Professor)

The National Cancer Institute (NCI), Center for Cancer Research (CCR), RNA Biology Laboratory is seeking an outstanding, internationally known scientist to lead an independent research group focused on any area of RNA biology.
Postdoctoral position in the Lab of Lynne Maquat, Ph.D., Director, Center for RNA Biology Professor, Departments of Biochemistry & Biophysics, Oncology, and Pediatrics, University of Rochester, NY

Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology to study one of a number of ongoing projects, including but not limited to FMRP function in Fragile X Syndrome (FXS), or effectors of nonsense-mediated mRNA decay efficiency. A background in neurobiology and/or stem-cell biology would facilitate the work on FXS, a background in computational biology would facilitate both projects, but neither is required.  
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