The RNA Transcript, October 26, 2020
TODAY, October 26, 9:00–10:00 am | U-M Center for RNA Biomedicine

UM RNA Innovation Seminar Series

Professor, The University of Western Australia Centre for Medical Research
"Regulation of the mitochondrial transcriptome in health and disease"


An interview with Dr. Peter Todd, M.D, Ph.D., Neurology, Medical School, University of Michigan (U-M), and member of the Executive Committee of the U-M Center for RNA Biomedicine
 
“Rare diseases” are not rare.
First off, rare diseases are not rare in aggregate- one in 10 (~30 Million) people in the US will suffer from a rare disease. Second, in many of these rare diseases, we have been able to define their genetic basis, and that has allowed us to model them effectively. This has led to targeted and effective therapies for a number of previously untreatable rare conditions.  
The University of Michigan Advanced Genomics Core, that performs RNA sequencing and collaborates closely with our Bru-Seq core lab, becomes "10x Genomics Visium Certified Service Provider."

The University of Michigan’s Advanced Genomics Core (AGC) has recently become a Certified Service Provider (CSP) of the 10x Genomics spatial transcriptomics platform known as Visium. This unique opportunity has been extended only to a few select institutions in the United States, with U-M being the only CSP in the Midwest.

Photo: A flow cell within a Gene Sequencing Chip at the Advanced Genomics Core
Did you miss it?
At World CRISPR Day 2020 (Tuesday, Oct. 20), panel discussion about the groundbreaking CRISPR documentary film "Human Nature," (documentary available on Netflix).

At the University of Michigan, many members of the Center for RNA Biomedicine are actively studying or using CRISPR technology and expanding its applications.
Professor, Neurosurgery
and Cell & Developmental Biology, Medical School
Dr Castro’s research program focuses on epigenetic regulation of brain cancer progression, uncovering the role of oncometabolites in the tumor microenvironment. Her program also aims to develop immunotherapies for primary and metastatic brain cancer, studying immune-biology mechanisms leading to clinical implementation. Our innovative work has led to an FDA approved immune-mediated gene therapy Phase 1 clinical trial for malignant brain cancer which recently completed accrual at the University of Michigan.

"A Role for “Doing Science” in Science Education"
A Special Zoom Lecture by Nobel Laureate Dr. Leland Hartwell


Keynote speakers:
Luke Wiseman, Ph.D., Associate Professor in the Department of Molecular Medicine at Scripps Research
Susan Ackerman, Ph.D., Investigator with the Howard Hughes Medical Institute, Steven W. Kuffler Chair of Biology, Neurobiology Section and Professor of Cellular and Molecular Medicine at the University of California, San Diego Medical School.

The registration deadline is Tuesday, October 27.
Wednesday, November 4, 4:00–5:00 pm EDT | RNA Collaborative Seminar Series, hosted by the University of Rochester Center for RNA Biology

“Tumors taking the short cut: CDK12 and CDK13 in early transcription termination and nuclear RNA surveillance”

“Targeting U2AF: A vulnerable rheostat of pre-mRNA splicing”


Friday, December 4 | 2020 Bay Area RNA Conference
Registration and abstract submission for the 2020 Bay Area RNA Conference are now open: https://barc.ucsf.edu

Once you are registered, you may submit speaker/poster presentation abstracts on your profile page, ie “Submit a New Presentation.” Deadline for abstract submissions: November 01.
 
Contact Elisabeth Paymal for press releases and blog articles of your upcoming publications. MORE INFORMATION

Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are recent highlights.
Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
Wu, X., Niculite, C.M., Preda, M.B. et al. Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORSNat Commun 11, 4755 (2020). https://doi.org/10.1038/s41467-020-18411-x

We hereby provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. 
Translational control in aging and neurodegeneration
Geena Skariah, Peter K. Todd, 20 September 2020, Wires RNA Wiley, https://doi.org/10.1002/wrna.1628

These new findings point to nodes in posttranscriptional gene regulation that both contribute to aging and offer targets for therapy.
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