Zuckerberg San Francisco General has played host to many films and television shows over the years. 5B (2018) is a documentary featuring the r emarkable people who built Ward 5B, the first AIDS ward unit in the United States, and changed the way patients were cared for during the 1980s AIDS epidemic.

Steve McQueen is chased through the tunnels under the hospital in Bullitt (1968) and the Bohemian Rhapsody (2018) news clip scene features Donald Abrams , ZSFG Medicine. Other scenes filmed on location include Fearless (1993), Nine Months (1995), Chance (2016), The Dead Pool (1988), Time After Time (1979) and the Streets of San Francisco no badge for Benjy scene filmed at the hospital's Main Gate.