Minneapolis Heart Institute Foundation

Interventional Research / Center for Coronary Artery Disease

Q2 2025

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Center Highlights

The CCAD Team is hosting two educational events at the MacMillan Center on AHMHI campus, both of which are in-person experiences that includes presentations, debates, discussions, hands-on training, and interactive live cases.

The Physiology Course June 5-6

Our expert faculty will delve into the latest research and advancements in coronary physiology, including wire-based and wireless approaches, providing valuable insights for cardiovascular professionals and researchers to improve patient care. 

Register Here

CT for PCI Summit 3.0 October 9-10

This interactive in-person program will include lectures by expert faculty in the field, hands-on training in the use of software to facilitate CT-guided PCI, in addition to live cases illustrating the role of pre- and intra-procedural planning.

Register Here

Study Spotlight: COSIRA ll


Description

This is a Coronary Sinus Reducer study to treat subjects with refractory angina in subjects with no other options left. The device works by creating a controlled narrowing of the coronary sinus which increases back pressure to improve blood flow to the heart muscle. It’s a randomized, blinded, sham controlled study.



Current Enrollment: 6 consented, 3 screen failures, and 1 randomized.

Contact

Lydia.Zenner@allina.com

Principal Investigator

Dr. Jay Traverse

Enrolling Clinical Studies

Study

Study Summary

PI and Enrolling Sites

REBIRTH

Minneapolis Heart Institute Foundation

Access site bleeding

Dr. Brilakis


ANW, Edina ASC

P4

Core Aalst

CCTA-guided PCI

Dr. Sandoval


ANW

Voice B

Minneapolis Heart Institute Foundation

Voice Biomarkers of burnout in healthcare providers

Dr. Brilakis


ANW

HARP

American Heart Association

MINOCA Imaging Study

Dr. Sandoval


ANW

ACT i-STAT

Abbott Vascular

IDE for new type of ACT cartridge in POC

Dr. Sandoval


ANW

SELUTION4 DeNovo

Med Alliance S.A.

DCB small vessel

Dr. Brilakis


ANW

MAGICAL ISR

Concept Medical

DCB for in-stent restenosis

Dr. Sandoval


ANW

ARTEMIS

Novo Nordisk

Drug Study to test safety and effectiveness of Ziltivekimab in reducing MACE when given early in STEMI and NSTEMI

Dr. Traverse


ANW

COSIRA II

Shockwave Medical

Coronary Sinus Reducer

Dr. Traverse


ANW, United

SSCORE

Zoll

SSo2 Utilization Registry

Dr. Traverse


ANW, United

PICANTE

Kardion

MCS devices for complex PCI IDE

Dr. Brilakis


ANW

SAPPHIRE 3

OrbusNeich

Coronary dilation catheter for predilation of CTOs

Dr. Brilakis


ANW

PK Papyrus Registry

Biotronik

Papyrus covered stent retrospective registry

Dr. Brilakis


ANW

Pipeline Studies

MOCA II

CorFlow

Microvascular obstruction detection pivotal IDE

Dr. Traverse


ANW

IRI-Explore

Boehringer-Ingelheim

STEMI drug trial

Dr. Traverse


ANW

Miron DFP

University of Indiana

First-in-human trial investigating use of deferiprone for the treatment of hemorrhagic MI

Dr. Traverse


ANW

Thrive

Sonivie

Renal Denervation Pivotal IDE

Dr. Wang


ANW

GSR Define RDN Registry

Medtronic

Global Renal Denervation (Simplicity system) registry

Dr. Wang


ANW

Forward CAD

Shockwave Medical

Javelin Coronary IVL catheter IDE

Dr. Brilakis


ANW

Abbott IVL

Abbott

IDE for IVL Catheter for mod to severe calcified lesions

Dr. Sandoval


ANW, United (pending)

Cobas

Roche

POC biomarker IDE

Dr. Sandoval


ANW

BIOFLOW 48

Biotronik

IDE for 48 mm Stent

Dr. Sandoval


ANW, United (pending)

ELEVATE III

Magenta Medical

Hemodynamic support device

Dr. Brilakis


ANW

Abbreviations: ANW = Abbott Northwestern Hospital; CTO = Chronic Total Occlusion; PCI = Percutaneous Coronary Intervention; IDE = Investigational Device Exemption; MCS = Mechanical Circulatory Support; DCB = Drug Coated Balloon; ACT = Activated Clotting Time; POC = Point Of Care; IVL = intravascular lithotripsy; STEMI = ST elevated myocardial infarction; NSTEMI = non-ST elevated myocardial infarction; MACE = major adverse cardiovascular events; CCTA = coronary CT angiogram; P4 = Precise Procedural and PCI Plan; HARP = Heart Attack Research Program; MINOCA = myocardial infarction with nonobstructive coronary arteries; SSO2 = Super saturated Oxygen; RDN = Renal Denervation; DFP = Deferiprone


For more information, please contact John Meriweather at john.meriwether@allina.com


Interested in clinical trials from our other areas of cardiovascular research? Visit mplsheart.org/archive for any recent emails you may have missed.