Minneapolis Heart Institute Foundation

Structural Research / Valve Science Center Update

May 2026 Bi-Annual Update

Dr. Vinnie Bapat, MD

James R. and Judith A. Bradshaw Chair Valve Science Center

Dr. Vinnie Bapat joined the Valve Science Center team in June 2020, bringing extensive expertise as a cardiothoracic surgeon and innovator in the treatment of heart valve disease. In recognition of his internationally renowned research and educational work in valvular heart disease, he was named the James R. and Judith A. Bradshaw Chair for the Valve Science Center. Read the Press Release

An Interactive Hands-on Training Course: 2026 TMVR/TTVR Planning Workshop May 8-9, 2026

In partnership with Pie Medical Imaging, expert physicians led an interactive, virtual workshop on CT planning for transcatheter mitral and tricuspid valve interventions — including valve-in-valve TMVR, valve-in-ring, valve-in-mitral-annular-calcification, and tricuspid procedures. Participants engaged in hands-on learning with 3Mensio software, received personalized instruction, and gained access to lectures and guided practice sessions.

Celebrating 1st Enrollments

BE-TAVI – First implant at MHIF of Abbott Medical’s balloon-expandable TAVR system
JenaVAD Registry – First enrollment in Minnesota of the Trilogy THV system for treatment of aortic regurgitation

Study Spotlight: ATLAS Pivotal Trial

Description

This clinical trial is designed to evaluate the safety and performance of the supra-annular AltaValve Transcatheter Mitral Valve Replacement (TMVR) system for the treatment of mitral regurgitation (MR).

Eligible patients include those with clinically significant MR (3+) deemed unsuitable for mitral valve surgery or transcatheter edge-to-edge repair (TEER). The trial also includes a MAC cohort with moderate MR (2+) and moderate MS, or severe MS regardless of MR grade.

Contact

Grant Emmerich

Grant.Emmerich@allina.com

612-863-3510

Principal Investigator

Dr. Vinayak Bapat

Enrolling Clinical Studies

Aortic

Study

Device

PI & Enrolling Site

ARTIST

JenaValve Technology

JenaValve Trilogy TAVR system vs. SAVR for patients with clinically significant aortic regurgitation

Dr. Mario Goessl

ANW

JenaVAD

JenaValve Technology

JenaValve Trilogy TAVR system for patients with a left ventricular assist device and clinically significant aortic regurgitation

Dr. Konstantinos Voudris

ANW

Journey

Edwards Lifesciences

J-Valve TAVR system for patients with symptomatic, severe aortic regurgitation

Dr. Konstantinos Voudris

ANW

PROGRESS CAP

Edwards Lifesciences

SAPIEN TAVR system vs. clinical surveillance for patients with moderate aortic stenosis

Dr. Bilal Murad

United

RESTORE

Medtronic

Registry for patients undergoing redo TAVR with Evolut and SAPIEN THV systems

Dr. Vinayak Bapat & Dr. Konstantinos Voudris

ANW

Mitral

AltaValve Pivotal/ATLAS

4C Medical Technologies

AltaValve TMVR System for patients with symptomatic moderate-to-severe or greater MR, or those with significant MAC and moderate MR/MS or severe MS

Dr. Vinayak Bapat

ANW

APOLLO

Medtronic

Intrepid TMVR system for patients with symptomatic moderate-to-severe or greater MR, or those with moderate or greater MR combined with MS and MAC

Dr. Mario Goessl

ANW

Cephea Early Feasibility

Abbott Medical

Cephea TMVR system for patients with symptomatic mitral valve disease, resulting in moderate-to-severe or greater MR and/or severe MS

Dr. Mario Goessl

ANW

Cephea MVD Registry

Abbott Medical

Observational registry for patients with symptomatic mitral valve disease in which TMVR is recommended over TEER or surgery

Dr. Mario Goessl

ANW

Tricuspid

Tandem II

CroiValve Limited

DUO Transcatheter Tricuspid Coaptation Valve System for patients with symptomatic, severe or greater tricuspid regurgitation

Dr. Anil Poulose

ANW

TRICURE EFS

TRiCares

Topaz TTVR system for patients with symptomatic, severe or greater tricuspid regurgitation

Dr. Vinayak Bapat

ANW

VISTA-US

Vdyne, Inc

VDyne TTVR system for patients with symptomatic, severe tricuspid regurgitation

Dr. Konstantinos Voudris

ANW

Pulmonary

PROPHET

Minneapolis Heart Institute Foundation

Study evaluating whether biomarkers can predict HALT and HAM after clinically indicated transcatheter pulmonary valve replacement in adults with congenital heart disease.

Dr. Mario Goessl

ANW

Pipeline Studies

DurAVR THV Anteris	Balloon expandable TAVR System for patients with aortic stenosis	Dr. Vinayak Bapat
MANTRA Corcym	Registry for patients undergoing procedure with commercially available Corcym devices	Dr. Vinayak Bapat
BoxX-NoAF Atricure	Left atrial concomitant ablation and left atrial appendage exclusion during cardiac surgery in patients without documented history of atrial fibrillation	Dr. Sebastian Iturra
Pathfinder Medtronic	Intrepid TTVR system vs Evoque in patients with severe symptomatic tricuspid regurgitation	Dr. Konstantinos Voudris
TRIVITA VDyne Inc	VDyne TTVR system vs Evoque in patients with severe symptomatic tricuspid regurgitation	Dr. Konstantinos Voudris
Treat TR Abbott Medical	Registry for patients undergoing commercial TriClip procedure	Dr. Mario Goessl

ANW=Abbott Northwestern; GDMT=Guideline-Directed Medical Therapy; HALT=Hypoattenuated Leaflet Thickening; HAM=Hypo-attenuation Affecting Motion; MAC=Mitral Annular Calcification; MR=Mitral Regurgitation; MS=Mitral Stenosis; MVD=Mitral Valve Disease; PI=Principal Investigator; TAVR=Transcatheter Aortic Valve Replacement; THV=Transcatheter Heart Valve; SAVR=Surgical Aortic Valve Replacement; TEER=transcatheter edge-to-edge repair; TMVR=Transcatheter Mitral Valve Replacement; TTVR=Transcatheter Tricuspid Valve Replacement

For more information, please contact Lisa Tindell at

Lisa.Tindell@allina.com; Ph 612-863-3816

Interested in clinical trials from our other areas of cardiovascular research? Visit mplsheart.org/archive for any recent emails you may have missed.