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                Weekly Updates in Pediatrics         July 4, 2012 

EDITOR:  Jack Wolfsdorf, MD


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Breast feeding protects against Asthma

A prospective study of 1,105 infants followed regularly over a 6 year period and adjusted for confounding influences indicates that for each month of exclusive breast feeding, a significant reduction in asthma occurs, a greater effect being seen in atopic infants exclusively breast fed for > 3 months. 

Source: Journal of Pediatrics, June 2012

Disability following Congenital Diaphragmatic Hernia (CDH ) repair

24-36mth follow up of 44 CDH survivors indicates that 27% have neurodevelopmental, 20.5% gastrointestinal, 11.4% pulmonary and musculoskeletal and hearing difficulties and 45% a cardiac disability, respectively. 


Source:  Journal of Pediatric Surgery, May 2012

Genetic polymorphisms in Idiopathic Nephrotic Syndrome (INS)

INS is the most frequent type of nephrotic syndrome in children. 74 children with INS categorized either as steroid-sensitive (SS) or steroid-resistant (SR) had genetic polymorphisms of the CYP3A5 and ABCB1 genes examined and comparisons made between those children who were SS or SR.


The C1236T polymorphism in the ABCB1 gene appears to be associated with INS steroid resistance in children.


Source: Pediatric Nephrology, June 2012

Neuroimaging & Prognosis in "Shaken Baby" traumatic brain injury (ITBI)

28 babies with ITBI had radiological studies performed during the acute phase (0-3 days) of injury and 4 days - 1 month later, and the clinical outcome of survivors compared to their radiological studies.

Both early and late radiological signs of significant brain abnormality (basal ganglia/brain stem) are associated poor long-term neurological outcome.


Source: Acta Paediatrica, June 2012


TBI in Young Children 4: Shaken Baby Syndrome and Normal Infant Crying
TBI in Young Children 4: Shaken Baby Syndrome and Normal Infant Crying

Source:  Brain Injury Association, Utah via YouTube

ECMO for Acute Respiratory Failure in a patient with Chronic Granulomatous Disease. (CGD)


CGD is a diverse group of hereditary diseases in which some of the cells of the immune system cannot generate, mostly, the superoxide radical required to kill ingested pathogens. Granulomata form as a result, in many organs.

This case report of a 9 year old CGD boy who presented with fulminant respiratory failure and who was treated with ECMO, and survived, indicates that a diagnosis of CGD should not be considered a contraindication to ECMO therapy.


Source:  Journal of Pediatric Surgery, May 2012

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