NON-MEDICATED LIFE

Hormesis and Xenohormesis
Potential Health Benefits

By Paul E. Lemanski, MD, MS, FACP

Medicines are a mainstay of American life and the healthcare system not only because they are perceived to work by the individuals taking them, but also because their benefit may be shown by the objective assessment of scientific study. Clinical research trials have shown that some of the medicines of Western science may reduce the risk of Type 2 diabetes, heart attacks, strokes, cardiovascular death and even some cancers.

In the previous installments of the Non-Medicated Life, a healthy diet and lifestyle have been shown to accomplish naturally for many individuals most of the benefits of medications in the prevention of the chronic medical conditions mentioned above. With respect to a healthy lifestyle and diet this column has suggested that moderate aerobic exercise and resistance training, the restriction of calories to maintain a normal body weight, and a predominantly whole foods, plant-based diet together produce health benefits. The mechanism of the health benefits may involve an adaptation to stress called hormesis or more simply: what doesn't kill us makes us stronger.

Hormesis is a biphasic dose–response phenomenon: a low dose of a stressor produces a beneficial, adaptive effect, while a high dose of the same agent causes harm. In toxicology, where the term originated, this appears as a characteristic inverted-U or J-shaped curve, with a threshold – the “zero equivalent point” – below which the stressor stimulates rather than inhibits.

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“Life is like a ten speed bicycle.
Most of us have gears we never use." – Charles Schulz

Thursday, November 12

Saratoga Outdoors: Fall Community Night: Thacher Climbing Coalition. 5-8pm. 30% of net sales donated to the nonprofit organization, plus $100 gift card to raffle. Saratoga Outdoors, Saratoga Springs. saratogaoutdoors.com.

Saturday, November 14

Girls on the Run 5K. 10am. Celebratory, non-timed run/walk. All welcome. Jennings Landing, Albany. gotrcr.org.

20th Albany Cranksgiving. Charity bike ride and food drive to benefit South End Children’s Cafe. Meetup: 11am. Ride: 12pm. Afterparty: 3pm. Kha & Mel’s Coffee-Tea Room, Albany. capitalstreets.org.

47th Annual Waitsfield Elementary Ski & Skate Sale. 9am-4pm. Find unbeatable prices on new & gently used alpine, snowboard, nordic, backcountry gear, ice skates, outerwear & accessories. Community members invited to consign new/gently used winter equipment/apparel. Waitsfield Elem. School, Waitsfield, VT. waitsfieldpta.org.

Cranksgiving. 10:30am. Annual "race" to donate food to Feeding Champlain Valley. See how many pounds of food you can ride with. Get a list of groceries and checkpoints and get riding! Free registration, prizes for heaviest load, best costume and more. Old Spokes Home, Burlington, VT. oldspokeshome.com.

Ski Movie Night. 6pm. Showing two new films. All Attendees receive 2-for-1 lift tickets. Snow Ridge Mountain Resort, Turin. snowridge.com.

Sunday, November 15

Upstate Classic Half Marathon & 5K. 9am. Scenic courses below Helderberg Escarpment. Kids run: 8:30am. An AREEP event. Altamont Fairgrounds, Altamont. upstateclassic.com.

Saturday, November 21

54th Sportsmart Gear Swap. 1-4pm. Scout Troop 75. Bethlehem High School, Delmar. troopwebhost.org.

Bolton PTO’s Turkey Trot 5K Run/Walk. 10:30am. Kids Block Trot 1M Fun Run/Walk: 10am. Veterans Memorial Park, Bolton Landing. boltoncsd.org.

Loaded Turkey Rail Jam. 9am. Frozen turkey for 1st place & all the fixings for 2nd & 3rd. Killington Resort, Killington. killington.com.

Thursday, November 26

79th Pioneer Troy Turkey Trot. 5K & 10K. 10K: 8am. 1M Walk & Grade School Mile: 9:30am. 5K: 10am. Troy Atrium, Troy. pioneertroyturkeytrot.com.

45th Ellis Medicine Cardiac Classic. 5K Race: 9am. 2M Wellness Walk: 8am. 1M Kids’ Fun Run: 10am. Central Park, Schenectady. cardiacclassic.org.

25th Christopher Dailey 5K Turkey Trot. 8:30am. Walkers welcome. Saratoga Hilton, Saratoga Springs. zippyreg.com.

Running of the Turkeys. 9am. Family-friendly 5K run/walk. Kids run: 8:45am. Fisher Elementary School, Arlington, VT. bkvtr.net.

Friday-Sunday, November 27-29

Audi FIS Ski World Cup: Stifel Killington Cup. Fastest female skiers compete in slalom and giant slalom. Superstar Trail, Killington, VT. killington.com

Thursday, December 3

Smugglers’ Notch Women’s Night. 5-7pm. An evening all about community, connection & carving out time for yourself. Win raffle prizes (grand prize: Women’s Program Registration & Bash Badge), learn about Smuggs’ Women’s Program & more. Burton Flagship Store, Burlington. smuggs.com.

Sunday, December 6

Adk TOUR de SKI: XC Ski Races. Season opener of the citizens XC ski race series. Mt Van Hoevenberg, Lake Placid. adktourdeski.com.

Thursday-Sunday, Dec. 10-13

Schenectady Wintersports Club: Early Season Ski Clinic. Small classes, instructors, group tickets, welcome party, happy hour. Lodging at SWC Clubhouse in Waterbury Center, VT. A Schenectady Wintersports Club event. Sugarbush Resort, Warren, VT. swcweb.org.

Friday-Sunday, Dec. 11-13

Smugglers’ Notch: Weekend Warrior. Kick off winter, skiing, and riding, and eat really well. Celebrating 70 years of Smuggs – special anniversary edition! Questions: groups@smuggs.com. Smugglers’ Notch Resort, Jeffersonville. smuggs.com.

Saturday, Dec. 12

Lapland Lake 10K Freestyle XC Ski Races. 10am. All welcome. Lapland Lake XC Ski Center, Northville. skireg.com.

Sunday, Dec. 13

HMRRC Doug Bowden Winter Series Run #1. 5K run/walk & 15K run. 10am. All welcome. Physical Education Building, SUNY Albany, Albany. hmrrc.com.

Whiteface Santa Sunday. All Day. Dress up as Santa or Mrs. Claus for a free lift ticket. Whiteface, Wilmington. whiteface.com.

RunVermont Freezy Cheeks 5K Series: First Frost. Open start: 11am-12pm. Embrace winter racing & stay on the move! Registration is open and includes a beverage. Discounts for registering with a buddy or for the entire four-race series (plus, get the 2027 Freezy Cheeks buff). Prizes for series winners and raffles from VT Brewers Assn. New location: American Flatbread, Stowe. runvermont.org.

Ongoing

MON-FRI Rock Your Fitness: Boot Camp Workouts. Mon/Wed/Fri: 5:30am, 6:30am, 9am. Tue: 5:30pm. Sat 8am. Special offer: Free week of class with registration for 2x/3x per week option. To register, text and use promo code “ADK fit” to 518-522-9765. Malta Community Center, Malta. facebook.com.