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Useful Tools for Nucleic Acid Contamination Removal

WHO and some countries have strict regulations on the residues of host nucleic acids. For example, the DNA residues of vaccines and therapeutic biological products are usually controlled below 100pg/dose and some products even no higher than 10pg. Therefore, effective removal of nucleic acids residues is a particular problem to concern.

To support the biologics research, ACROBiosystems has developed the premium grade GENIUS™ Nuclease product with high enzyme activity and excellent safety profile.

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What can premium grade GENIUS™ Nuclease do for you?

Elimination of nucleic acids from biologics

✓ Preclinical viral vaccine production, which will transit from preclinical development to clinical phases.

✓ Preclinical viral vector production for cell and gene therapy（CGT）,which will transit from preclinical development to clinical phases.

✓ Other preclinical development and production uses

Why choose premium grade GENIUS™ Nuclease?

✓ Same activity and performance with GMP Grade Nuclease

✓ Enables a seamless transition from preclinical development to clinical phases

✓ Easily transit into clinical and commercial phases and avoid needing to amend your manufacturing process and undertake comparability studies.

What is GENIUS?

✓ Generally usable: Generally usable for removing all forms of DNA and RNA from biological products, reducing viscosity and preventing cell clumping.

✓ Efficient: Efficient reaction, rapid degradation, reduce processing time.

✓ Native: Native structure, tag free, the enzyme activity is more guaranteed.

✓ Ideal: Ideal for DNA and RNA clearance.

✓ Ultra-pure: High purity and activity.

✓ Specific: Specific nuclease, no protease activity.

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Data

✧ GENIUS™ Nuclease, premium grade shows high specific activity than that of other competitors

Specific activity for GENIUS™ Nuclease, premium grade is measured under standard assay conditions. The specific activity of GENIUS™ Nuclease, premium grade is >1.2 x 10e6 units/mg protein. One unit will digest sonicated salmon sperm DNA to acid-soluble oligonucleotides equivalent to a ΔA260 of 1.0 in 30 min at pH 8.0 at 37 ℃, which corresponds approximately to complete digestion of 37 μg DNA. Note that 1 KU=1000 units.