February 7, 2017
The long-acting, nonhormonal contraceptive -- for men.
It's official: Vasalgel effective in monkeys
No pregnancies in over a year -- study published today
Rhesus macaque
If you've been following Vasalgel updates, you heard last November that Vasalgel worked and was safe in rhesus monkeys, and that the results were submitted for publication. Now it's official! After 16 male monkeys received Vasalgel, none of them caused pregnancies during the year-plus period of a study at the California National Primate Research Center, according to a report just published in Basic and Clinical Andrology ( see the report here).

The study sought to bring Vasalgel one step closer to human use by testing it in animals that are anatomically similar to humans. It followed and exceeded the more humane European standards for animal research in accordance with Parsemus Foundation policy. As part of humane housing, the males lived in social groups including three to nine females -- plenty of chance for pregnancies!

rhesus macaque
The study's success indicates that in addition to benefiting humankind, Vasalgel may become a useful tool for those who care for primates in zoos and breeding programs.

"Vasectomy is a quick and relatively simple procedure in humans, but in monkeys there can be additional complications, as it is inherently more complex," Dr. Angela Colagross-Schouten, lead veterinarian on the project, said. "We were impressed that this alternative worked in every single monkey, even though this was our first time trying it."
Monkey results have positive implications for humans
Success reaching the two key goals: efficacy and safety
Stacked Blocks Showing Progress
The success of Vasalgel in monkeys is the most promising evidence yet for the eventual success of Vasalgel in humans.

One significant takeaway is that Vasalgel proved effective over a long period of time; seven of the 16 males that received the contraceptive were almost continually housed with fertile females for two years (the others were housed with females for a single breeding season). The monkeys lived in social groups in an outdoor setting that was similar to the natural environment, in which mating would typically result in reproduction.

The monkeys also had a good response to Vasalgel, with fewer complications than an age-matched control group that received vasectomies. This safety data is encouraging for the prospects of the upcoming human clinical trials.

Though the monkey study did not test the reversibility of Vasalgel, the successful reversibility study in rabbits has just been accepted for publication, so stay tuned for details in a future Vasalgel Update.
Note about clinical trials
Q: How do I sign up for a clinical trial?
Hourglass of patience
It's the #1 question about Vasalgel: How do I participate in an upcoming clinical trial?

The good news: If you're reading this update, you're already signed up to be the first to hear. But here's the catch: The selection of clinical trial participants will be completed by the doctor in charge of the trial, based on criteria in the clinical trial protocol. The physician will have a say in deciding age, health status, how far people can travel, etc. And the city will be chosen partly by where we find a great partner clinician.

We'll be moving forward with a ramped-up team (stay tuned for upcoming news) and hitting these issues on all fronts this year.

When details are available -- including any opportunities for trial participants -- we'll notify our Facebook and Twitter fans and we'll contact our email subscribers (which means you). In the meantime, you have a ringside seat on what it takes to develop a new contraceptive. Stay tuned!
We're working hard and are grateful for your support!

Sincerely,
the Vasalgelâ„¢ team

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