Late fall sunrise on Camel's Hump Riley Momenee | | An ice bath, a popular example of hormesis istock | | |
Hormesis and Xenohormesis– Potential Health Benefits
By Paul E. Lemanski, MD, MS, FACP
Medicines are a mainstay of American life and the healthcare system not only because they are perceived to work by the individuals taking them, but also because their benefit may be shown by the objective assessment of scientific study. Clinical research trials have shown that some of the medicines of Western science may reduce the risk of Type 2 diabetes, heart attacks, strokes, cardiovascular death and even some cancers.
In the previous installments of the Non-Medicated Life, a healthy diet and lifestyle have been shown to accomplish naturally for many individuals most of the benefits of medications in the prevention of the chronic medical conditions mentioned above. With respect to a healthy lifestyle and diet this column has suggested that moderate aerobic exercise and resistance training, the restriction of calories to maintain a normal body weight, and a predominantly whole foods, plant-based diet together produce health benefits. The mechanism of the health benefits may involve an adaptation to stress called hormesis or more simply: what doesn't kill us makes us stronger.
Hormesis is a biphasic dose–response phenomenon: a low dose of a stressor produces a beneficial, adaptive effect, while a high dose of the same agent causes harm. In toxicology, where the term originated, this appears as a characteristic inverted-U or J-shaped curve, with a threshold – the “zero equivalent point” – below which the stressor stimulates rather than inhibits...
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“It's really about being average a lot of the time.”
― Phily Bowden
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Saturday, November 14
47th Annual Waitsfield Elementary Ski & Skate Sale. 9am-4pm. Find unbeatable prices on new & gently used alpine, snowboard, nordic, backcountry gear, ice skates, outerwear & accessories. Community members invited to consign new/gently used winter equipment/apparel. Waitsfield Elem. School, Waitsfield, VT. waitsfieldpta.org.
Cranksgiving. 10:30am. Annual "race" to donate food to Feeding Champlain Valley. See how many pounds of food you can ride with. Get a list of groceries and checkpoints and get riding! Free registration, prizes for heaviest load, best costume and more. Old Spokes Home, Burlington, VT. oldspokeshome.com.
2nd Annual Upper Valley Cranksgiving. 10am. A food drive on two wheels: part bike ride, part food drive, part scavenger hunt. White River Junction. cranksgiving.org.
Girls on the Run 5K Run/Walk. 10am. A fun celebratory 5K where first-timers, friends/family, and seasoned pros are all welcome to challenge yourself and support a worthy cause. All proceeds benefit Girls on the Run Capital Region’s scholarship program. Jennings Landing, Albany, NY. gotrcr.org.
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Sunday, November 15
Upstate Classic Half Marathon & 5K. 13.1M: 9am. 5K: 9:10am. Scenic courses below Helderberg Escarpment around rural Guilderland. Also, 1M & 0.5M Kids Races (ages 12-under): 8:30am. An ARE Event Productions event. Altamont Fairgrounds, Altamont, NY. upstateclassic.com.
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Saturday, November 21
Mount Ascutney Vertical Backyard. 9am. A "Last Person Standing" event. Each hour participants will ascend (and descend) 1209 vertical feet via one of two routes. The race ends when there is only one person left. Ascutney Outdoors, Brownsville, VT. ultrasignup.com.
Westford Turkey Trot - Run for the Rink. 10am. Scenic race to support children & families of Westford. This year’s race will help to purchase a new community ice rink! 3K, 10K & Tot Trot. Westford Elementary School, Westford, VT. runreg.com.
Burrows Sports Cranksgiving. Time TBD. Ride your bike, raise money & collect food for the First Congregational Church. West Brattleboro. burrowssports.com.
Loaded Turkey Rail Jam. 9am. Frozen turkey for 1st place & all the fixings for 2nd & 3rd. Killington Resort, Killington. killington.com.
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Saturday-Sunday, November 21-22
Wilderness First Aid. 16 hour, hands-on course to prepare for backcountry medical emergencies. Focus on prevention, recognition & treatment. Green Mtn Club, Waterbury Center, VT. greenmountainclub.org.
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Sunday, November 22
ORO Cranksgiving. 10am. A food drive on wheels! Start at the ORO shop & ride to 3 stores to pick up groceries. All food will be donated to Just Basics, the Montpelier Community Food Pantry. See who’s fastest, which load is heaviest & who donates the most food! Onion River Outdoors, Montpelier. onionriver.com.
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Thursday, November 26
31st Running of the Turkeys. 5K family-friendly road race & walk: 9am. 1K Kids Fun Run: 8:45am. Traditional Thanksgiving run/walk. Scenic course, a few hills, and a friendly spirit. Turkey bling to the first 200. Family discount. Kids run: $1. Fisher Elementary School, Arlington, VT. runsignup.com.
50th GMAA Turkey Trot 5K Food Drive. 5K run/walk on the UVM women’s XC course: 10am. Suggested donation of $5/person or $10/family to benefit Feeding Chittenden, and/or bring a food donation. Also, free 1/4-Mile Kids Race: 9:45am. Gutterson Field House, Burlington, VT. gmaa.run.
Castleton Turkey Trot. 8am. A family-friendly 5K through historic Main Street & scenic D&H Rail Trail. Castleton. ultrasignup.com.
15th Annual Killington Turkey Trot. 9:30am. 5K race & festivities benefiting Killington Search & Rescue. Pickle Barrel, Killington. killington.com.
Jeff RUN sonville Turkey Trot. 8am. 5K and 2K on the beautiful Cambridge Greenway Trail. Jeffersonville, VT. trifind.com.
Gobble Gobble Wobble 5K. 9am. Trot through the village w/ Stratton's scenic backdrops during this annual family-friendly Thanksgiving race. Award for best costume! Stratton Village, VT. stratton.com.
Zack’s Place Turkey Trot. 10am. A joyful start to Thanksgiving & fundraiser for the programs at Zack’s Place. Live music & warm drinks. Woodstock Elementary School, Woodstock, VT. runsignup.com.
79th Pioneer Troy Turkey Trot. 10K: 8am. Grade School Mile: 9:30am. Troy Mile Walk: 9:35am. 5K: 10am. Costume contest. Troy Atrium, Troy, NY. pioneertroyturkeytrot.com.
45th Ellis Medicine Cardiac Classic. 5K Road Race: 9am. 2M Wellness Walk: 8am. 1M Kids Fun Run (free): 10am. Virtual 5K option. Central Park, Schenectady, NY. cardiacclassic.org.
25th Christopher Dailey 5K Turkey Trot. 8:30am. 5K Run/Walk. Family discount rate. Virtual option. Saratoga Hilton, Saratoga Springs, NY. christopherdaileyfoundation.com.
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Friday-Sunday, Nov. 27-29
Audi FIS Ski World Cup: Stifel Killington Cup. Fastest female skiers in the world compete in slalom and giant slalom. Fans can enjoy lots of festivities. Superstar Trail at Killington, Killington, VT. killington.com.
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Thursday, December 3
Smugglers’ Notch Women’s Night. 5-7pm. An evening all about community, connection & carving out time for yourself. Win raffle prizes (grand prize: Women’s Program Registration & Bash Badge), learn about Smuggs’ Women’s Program & more. Burton Flagship Store, Burlington. smuggs.com.
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Saturday, December 5
Reindeer 5K Run/Walk. 9:30am. Reindeer race shirts: register by 11/17 for size guarantee. Discounted youth registration. An Adirondack Runners event. Benefits Wait House. SUNY Adirondack, Queensbury, NY. zippyreg.com.
Slab-a-palooza. A celebration of slab climbing. All are welcome, no experience necessary. Petra Cliffs, Burlington. petracliffs.com.
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Saturday-Friday, December 5-11
Stratton Kids Ski & Snowboard Free Week. Ages 17 and under ski/snowboard for free, plus deals on lessons & rentals. Stratton Resort, Stratton. stratton.com.
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Friday-Sunday, Dec. 11-13
Smugglers’ Notch: Weekend Warrior. Kick off winter, skiing and riding, and eat really well. Celebrating 70 years of Smuggs – special anniversary edition! Questions: groups@smuggs.com. Smugglers’ Notch Resort, Jeffersonville. smuggs.com.
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Saturday, Dec. 12
Rodrigues XC Ski Sprints. FIS-sanctioned classic sprint race for all comers. Craftsbury Outdoor Center, Craftsbury Common. craftsbury.com.
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Saturday-Friday, Dec. 12-18
Sugarbush Kids Ski & Snowboard Free Week. Ages 12 and under ski/snowboard for free, plus deals on lessons. Sugarbush Resort, Warren. sugarbush.com.
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Sunday, December 13
RunVermont Freezy Cheeks 5K Series: First Frost. Open start: 11am-12pm. Embrace winter racing & stay on the move! Registration is open and includes a beverage. Discounts for registering with a buddy or for the entire four-race series (plus, get the 2027 Freezy Cheeks buff). Prizes for series winners and raffles from VT Brewers Assn. New location: American Flatbread, Stowe. runvermont.org.
Tom Kendall Memorial XC Ski Race. 7.5K open, 5K U16 skate race. Craftsbury Outdoor Center, Craftsbury Common. craftsbury.com.
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Wednesday-Sunday, December 16-20
US Biathlon On-Snow International Team Trials. Senior level racers hoping to qualify to race for Team USA in Europe. Volunteers needed. Craftsbury Outdoor Center, Craftsbury Common. craftsbury.com.
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Sunday, December 20
Winter Solstice Party. 10am-2pm. Gather your crew to welcome winter w/ music, a lively party on the Stache Deck, sweet raffle prizes & more. Smugglers’ Notch, Jeffersonville. smuggs.com.
Santa Sunday. Anyone dressed as Santa, Mrs. Claus or the Grinch gets a FREE lift ticket for the day! Bolton Valley Resort, Bolton Valley. boltonvalley.com.
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Ongoing
DAILY GMAA Group Runs. Check website for details. gmaa.run.
T-TH Catamount Night Loop. 4-8pm. Nordic skiing under the lights. Open Tue, Weds, Thurs. *Snow dependent, beginning Dec 8*. Catamount Outdoor Family Center, Williston. catamountoutdoor.org.
Wed Frosty Turtles Group Run. 5:30pm. Winter social run/walk group meets weekly through February. Fleet Feet, Essex Junction. fleetfeet.com.
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