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Structure-based vaccine design finally made its first breakthrough with the first-in-class RSV vaccine approval of GSK’s Arexvy and Pfizer’s Abrysvo.

A deeper look into protein structure is warranted, especially stemming from this success. This was especially apparent for RSV, where the RSV envelope glycoprotein F plays an important role in RSV binding. During infection, the conformation of F protein changes from an unstable pre-fusion (pre-F) conformation to a highly stable post-fusion (Post-F) conformation. Evidence has suggested that Pre-F triggers higher levels of potent antibodies than post-F. As such, the concept of stabilizing glycoproteins in the Pre-F form is now being successfully applied to closely related viruses, such as Nipah virus, Hendra virus, etc. 

ViruStop: Solutions for Vaccine and Antiviral Drug Development 

To accelerate the development process of structure-based vaccine, solve the bottlenecks of vaccine development for complex viruses, ACRO ViruStop^TM has developed a series of viral surface antigens in multiple natural conformation, including pre-fusion, pre-hairpin intermediate, post-fusion etc. covering RSV, NiV, HeV, HIV, Influenza, VZV, Coronavirus and other viruses of interest.

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