Why can’t Bertrand cry? Scientists offer an answer: missing water channels
In 2012, then-four-year-old Bertrand Might became the first person in the world to be diagnosed with NGLY1 deficiency. In a recent study, Hudson Freeze, Ph.D., has shown that cells from children with the condition lack sufficient water channel proteins called aquaporins. Published in
Cell Reports, the discovery offers an explanation for the disorder’s wide-ranging symptoms, which include inability to produce tears, seizures and developmental delay, and opens new avenues to find therapies to treat the disorder.
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Boosting the immune system's ability to fight cancer
Cancer immunotherapies have revolutionized the treatment of certain cancers, but they don't work for everyone. Ze'ev Ronai, Ph.D., has shown that the Siah2 protein helps control immune cells called T regulatory cells, which limit the effectiveness of immunotherapies. The research, which offers a new way to pursue immunotherapy in cases where the treatment fails, was published in
Nature Communications.
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For worms, a cellular recycling protein is the key to a long life
Malene Hansen, Ph.D., and Caroline Kumsta, Ph.D., have shown that worms live longer if they produce excess levels of a protein, p62 or SQSTM1, which recognizes toxic cell proteins that are tagged for destruction. The discovery, published in
Nature Communications, could help uncover treatments for age-related conditions such as Alzheimer’s disease, which are linked to the accumulation of misfolded proteins.
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Breast cancer expert Brooke Emerling receives Forbeck Scholar Award
The William Guy Forbeck Research Foundation has selected Brooke Emerling, Ph.D., as a Forbeck Scholar, a prestigious award that recognizes early-career cancer researchers for their achievements and dedication to the field. As an award winner, Emerling receives access to several three-day “think tank” events featuring the world’s top cancer clinicians and scientists—connections that will accelerate her work to create therapies that help more breast cancer patients live longer, healthier lives.
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Pancreatic cancer experts gather at Sanford Burnham Prebys
Russell Gold is lucky to be alive: Only 9% of those with pancreatic cancer survive longer than five years. To help educate people about why pancreatic cancer is so lethal—and the latest efforts to develop new medicines—our Institute hosted a discussion featuring Gold, a scientist and a clinician, all working on pancreatic cancer.
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How to help children thrive after a brain cancer diagnosis
Brain tumors are the most common cause of cancer-related deaths in children. To help the public learn about the latest efforts to develop better treatments for pediatric brain cancer, our Institute partnered with the Fleet Science Center to host a panel discussion featuring a young survivor, a scientist and a clinician.
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Raise a solo cup for medical research
Co-chairs Melissa and Scott Murfey, and Sheri and Steven Spector invite you to bring your sense of humor and have fun while you team up for the most unique event in San Diego:
Bring It! This high-intensity, game-show experience supports our goal of making groundbreaking discoveries that lead to tomorrow’s cures. We hope you can join us on Thursday, April 30, at the Del Mar Fairgrounds.
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At Sanford Burnham Prebys, we are passionate about finding bold new ways to treat disease, and we recognize the importance of sharing our discoveries with the public. Find out where and when you can meet our scientists and learn about their research in this
community event calendar.
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Catalyst Club
Become part of a special community of Sanford Burnham Prebys supporters by joining our new monthly giving club. You will also receive a beautiful and sleek black Sanford Burnham Prebys Catalyst Club tote bag, perfect for your everyday needs.
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