FOCUS on Research

Whole Health Research May Provide Treatment Answers for Opioid Crisis

Karen Seal, MD, MPH
As a physician and clinic director with the San Francisco VA Health Care System, Dr. Karen Seal strives to treat patients holistically, as opposed to focusing narrowly on a disease or symptom.

For scores of Veterans who suffer chronic pain - usually with other ills from the physical and mental wear and tear of military service - promoting whole-person wellness is especially crucial. 

Current treatments for chronic pain often rely on opioids, which have limited efficacy, are addictive and could cause a host of severe complications. Many experts agree that reliance on opioids has fueled what is now a national crisis. 

As a researcher, Seal leads a new national study on Whole Health approaches that include interdisciplinary teams of pain care professionals, personalized health planning, peer coaching and evidence-based complementary and integrative models to manage pain in Veterans. 

Steven Yukl, MD
Q and A:

An Interview with Steven Yukl, MD
Staff Physician, Medical Service, SFVAHCS 
Associate Professor of Medicine, UCSF

Q: Describe your lab's research and how it is helping to better understand and treat HIV

A:  My laboratory seeks to understand some of the mechanisms that prevent HIV from being cleared by the immune system or antiviral drugs. These include the ability of HIV to establish a reversibly silent, hidden infection in some CD4+T cells in the blood ("latent infection"), the persistence of larger numbers of infected cells in the tissues, the fact that HIV disables the immune system, and the possibility that existing drugs might not completely block spread of virus within the body.  Our laboratory studies most of these different obstacles to the cure of HIV. 
Phishing E-mails

Advice from NCIRE IT

Phishing scams are typically fraudulent e-mail messages appearing to come from legitimate enterprises. These messages usually direct you to a spoofed website and get you to provide private information such as username and password.

While the e-mail filtering engine on the e-mail server has improved over the years, there is no absolute method to prevent phishing e-mails from getting to the inbox. We all need to be aware of phishing e-mails and take precautions.
  • Do not respond to any e-mail requesting personal or financial information. If the e-mail sender is a company you know or someone you know, call them to verify if information is needed using the number on their company websites or in your address book, not the number in the e-mail.
  • Do not click on links or open attachments in a suspicious e-mail message. These could potentially contain malware or ransomware.
If you are not sure if an e-mail you received is a phishing e-mail, please don't hesitate to contact the NCIRE IT Helpdesk (2-3939 or for assistance.
Here's an article on how to recognize phishing e-mail messages.

Contracts and Grants

NCIRE's Contracts and Grants Department continues to provide resources to our
PI Community. Please find the following useful links:
NCIRE's Intranet at Your Fingertips

Please find the following useful links: 
Employee Notifications

ReQlogic has been upgraded to version 11, which resolves a significant compatibility issue. All punch out vendors are functional now. Contact  with questions.
Human Resources

2018 Employee Handbook

Message from the Chief Executive Officer

Rebecca Rosales, MBA, CRA  

The last few months at NCIRE have been transitional as we cope with several challenges and financial concerns. I understand the distraction and the anxiety that many of you feel. Please be assured that NCIRE leadership and our administrative staff, with the support of our Board of Directors, is committed to promoting NCIRE's ability to be flexible, to facilitate research, to maximize the impact of research outcomes, and to ensure efficient use of resources.  Our Contracts and Grants Team continue to update funding opportunities for our research community, and they are always available to assist you throughout the application process and provide grant management support for the duration of your project.
  • We are exploring ways to diversify our research portfolio and will now consider approving applications for foundation grants on a case-by-case basis. 
  • The latest Contracts and Grants opportunities can be found at the following links: Industry Funding Opportunities and Federal Funding Opportunities
  • As of July 24th, NCIRE has facilitated the submission of 77 applications this fiscal year, and 13 awards have been funded. We have initiated 20 new CRADAs and have received $2.9 million in industry revenue during the first nine months of fiscal year 2018, which exceeds the total received for the entire previous fiscal year.
I thank you for your dedication and hard work, and for your partnership with NCIRE. I would really like to hear from all you; please share your thoughts ( As always, you have remained focused on our important mission to Advance Veterans Health.

Rebecca Rosales, MBA, CRA

NCIRE - The Veterans Health Research Institute has one mission and one goal: Advancing Veterans Health. We sustain a scientific community of clinicians and researchers and support over 200 researchers who have joint faculty appointments at the University of California,
San Francisco (UCSF) and the San Francisco VA Health Care System (SFVAHCS) and
are working to foster innovation through leadership in the field of Veterans health research. Our broad portfolio of projects receives generous support from the National Institutes of Health, the Department of Defense, and individual donors, making us the largest nonprofit research institute devoted to Veterans health in the U.S. NCIRE is a 501(c)3 nonprofit.
(Tax ID #94-3084159). Visit NCIRE at