Ok you are still reading so clearly you are curious or like myself was experiencing FOMO. I have had many patients on GLP-1s that have not just lost weight but have had their lives changed and I have yet to see any negative consequences with exception of some nausea. Of course i became curious if these peptides were effecting other body systems as well. While most people have heard that GLPs increase satiety by slowing gastric emptying and make patients feel less hungry but there was something else going on. Patients were also reported decreased cravings for all things such as alcohol and this has had tremendous benefits for those struggling with sugar and alcohol. But wait there is more, people reported a sense of improved mood, improved cognition, less body aches, decreased and elimination even of autoimmune syndromes, improved cardiovascular health. Well of course that would happen right...I mean if you are losing weight, those parameters should improve but in fact the mechanisms something more and is found to help even in microdoses in patients that are metabolically healthy.

GLPs have anti-inflammatory properties by reducing levels of interleukin-6, tumor necrosis factor alpha and high sensitivity c-reactive protein.

GLPs have shown to have neuro protective effects and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein involved in regulating the innate immune system and inflammatory responses.

GLP-1 receptors are also found on different immune cells, such as neutrophils and eosinophils, and their activation has modulatory effects on immune responses and inflammatory responses associated with these types of cells

Unless you live under a rock you have probably learned by know that inflammation is the cause of the majority of disease, inflammation is caused by diet and lifestyle and sadly most of us are so addicted to our diets and habits that real change is hard. The body is very resilient and will always repair (hence inflammation) until it can not. this is where these magical peptides can help. The are not "drugs" per se but peptides that work at the cellular level to repair, or help your body repair itself.

Can micro dosing fix all your health problems...normally i would say of course not, but honestly the changes I have seen have been dramatic especially in those committed to making lifestyle changes.

I have created my own micro-dosing protocol that includes other antioxidants that I feel are beneficial for health (Glutathione and NAD).

NAD https://www.thesshh.com/nicotinamide-adenine-dinucleotide-nad-injections/

Glutathione https://www.thesshh.com/glutathione-shots-50-shots-friday-only/

The injection is still weekly, the GLP is dosed low enough that nausea is very unlikely but I also include a small amount of zofran in the injection to offset this side effect as well. For more information of pricing or get started you may call the office at 480-419-6996 or

txt me directly 480-861-0338 I rarely answer my phone so please txt ;)

Thanks for reading!

Stefanie PhD, FNP-C, ENP-C, FAARM, NREMT

Yaribeygi H, Maleki M, Jamialahmadi T, Sahebkar A. Anti-inflammatory benefits of semaglutide: State of the art. J Clin Transl Endocrinol. 2024 Mar 28;36:100340. doi: 10.1016/j.jcte.2024.100340. PMID: 38576822; PMCID: PMC10992717.

L Lobo, W Masson, J P Nogueira, M Rodriguez Granillo, L Barbagelata, D Siniawski, G Molinero, A Levalle Cobo, E Salmieri, V Sarli, J Delgado, M Nemec, Anti-inflammatory effect of semaglutide: updated systematic review and meta-analysis, European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2917, https://doi.org/10.1093/eurheartj/ehae666.2917