In the latest issue of Discoveries:

Discovering a genetic disease

Demonstrating a computational model that measures telomeres

Automating the analysis of genome sequencing

Understanding the causes of liver damage

Revealing how ovarian cancer outmaneuvers the immune system

Celebrating 50 years of discovery

Scientists discover a new genetic disease that causes premature aging and cognitive deficits

The Zhang lab and an international team of collaborators combined genome sequencing with cellular reprogramming to identify the gene mutation responsible for a newly discovered disease and to study how it causes the symptoms observed in patients.

Computational model measures key aging metric from routine biopsies

The Sinha lab developed a new computational tool that infers changes occurring at the ends of chromosomes. It does so by detecting structural alterations in cells and tissues captured in images of medical biopsies.

New computational biology tool automates and standardizes genome sequencing analysis

The Boutros lab recently published results from building and testing a new computational tool for tackling massive, complex genome sequencing datasets. The resource, named metapipeline-DNA, may help standardize sequencing data analysis across different research labs.

Living LARP6: How a protein plays an oversized role in liver fibrosis

Metabolic syndrome can cause liver damage and resulting fibrosis or scarring, which impairs organ function and can lead to cirrhosis, cancer and failure. A new study from the Brenner lab further illuminates the function of a protein that plays a key role in regulating fibrosis development and represents a potential therapeutic treatment.

Overcoming ovarian cancer’s resistance to immunotherapy

The Tharp lab collaborated on a study showing how ovarian cancer evades the immune system. The preclinical results suggest the need to test combination therapies using focal adhesion kinase inhibitors, chemotherapy and immunotherapy.

Join us in reflecting on our 50th anniversary and a bright future

We are celebrating 50 years of discovery at Sanford Burnham Prebys and we’d like to invite you to celebrate this milestone anniversary with us. For more than half a century, Sanford Burnham Prebys has been shaped by bold ideas, dedicated scientists and a shared commitment to discovery—we hope these upcoming events inspire you with our past and excite you for our future.

View photos from five decades of research and education

This year marks 50 years of Sanford Burnham Prebys. 🎉🎉🎉

Our photo gallery offers a behind-the-scenes look at the people behind the discoveries. It includes our founders, faculty members, postdoctoral researchers, graduate students and community supporters. See who has helped us translate science into health for 50 years and counting.

‘A novel approach’: Sanford Burnham Prebys celebrates 50 years of medical exploration

From its beginnings as a small cancer research foundation to a leading biomedical institute, Sanford Burnham Prebys marks 50 years of collaborative discovery.

Colorized scanning electron micrograph of human lung tissue, depicting alveoli and bronchus. Lung alveoli are tiny, grape-like sacs, numbering in the millions, where essential gas exchange (oxygen/carbon dioxide) occurs. The bronchus is a major airway that branches from the trachea to conduct air into the lungs. Image courtesy of Ali Erturk, Munich, Germany.