The RNA Transcript, March 8, 2021 |
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Together, with your support for RNA research,
we solve COVID-19, cancer, rare diseases, ....
THANK YOU FOR YOUR SUPPORT!
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Chemistry, College of LSA - Faculty: Nils G. Walter
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I am interested in chemistry at the interface with biology and medicine. I have always had an interest in understanding the pathology of a disease. Through my research, I am working on a diagnostic tool that detects microRNA (miRNAs) molecular profiles to help better understand human health and predict the likelihood of human disease. Click here for her "RNA Featured Researcher" page.
Montoya’s interests in biosciences were sparked in part by “Osmosis Jones,” an animated action comedy about one white blood cell’s race against the biological clock to hunt down and destroy a lethal new virus. Click here for "her story."
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In case you missed it:
March 3rd, we hosted an RNA Collaborative Seminar with Melissa Moore, Ph.D., Chief Scientific Officer at Moderna Therapeutics (webinar abstract). The attendance was over 1,400 participants. Michigan Science Writers, a graduate student organization at the University of Michigan whose goal is to train fellow graduate students & post-doctoral fellows in science writing and editing, kindly covered this event for us. Visit their blog.
Fun fact: By the end of 2021, Moderna will have produced 140 kgs of RNA!
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Tuesday, March 9, 12:00 pm EST | U-M Biological Chemistry, Medical School Greenberg Lecture
“Mechanistic Insights into the mRNA Poly(A) Tail Machinery”
MRC Laboratory of Molecular Biology, Cambridge, UK
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Tuesday, March 9, 3:00 pm EST | U-M short course, co-sponsored by the Genetics Training Program (GTP) and the Program in Cellular and Molecular Biology (CMB)
"Regulating Transcription and Coding and Non-Coding RNA Loci"
Karen Adelman, Ph.D., Departments of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
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Wednesday, March 10, 4:00 pm EST | RNA Collaborative Seminar Series, hosted by Alberta RNA Research and Training Institute (ARRTI), Lethbridge
“Grad School to Biotech: A start up perspective”
“RNA Innovation: The power of academic and industry collaborations”
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Wednesday, March 10, 4:00 pm EST | U-M CCMB / DCMB Weekly Seminar Series
"Translation of single-cell and spatial transcriptomics into human health: methods and applications"
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Wednesday, March 10, 3:00 am EST (5:00 pm Seoul, Korea) | Center for RNA Science at Institute for Basic Sciences
Ling-Ling Chen (CAS), Yong Sun Lee (NCC), Noam Stern-Ginossar (WIS)
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Thursday and Friday, March 11 and 12 | National Heart, Lung, and Blood Institute (NHLBI)
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Friday, March 12, 12:00 pm EST | U-M Biophysics Seminar Series
“Can artificial intelligence help understand and predict biomolecular dynamics?”
Pratyush Tiwary, Ph.D., Department of Chemistry & Biochemistry and Institute for Physical Science & Technology, University of Maryland
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Monday, March 15, 4:00 pm EST | U-M Center for RNA Biomedicine, RNA Innovation Seminar
“Programmable transcriptional memory by CRISPR-based epigenome editing”
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OUR 5TH ANNUAL RNA SYMPOSIUM, MARCH 25–26, 11:00–2:30 pm |
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KEYNOTE SPEAKER 5,
Friday, March 26, 12:10–1:05 pm
Christopher Lima, Ph.D.,
Sloan-Kettering Institute
“Mechanisms that target RNA for destruction”
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The Symposium is sponsored by the
University of Michigan Biosciences and Lexogen
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.........................
Of our five keynote speakers, which scientist is most likely to talk about CRISPR?
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Choose below - See the answer next week!
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Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are recent highlights.
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Keywords:
ATP hydrolysis; group I intron ribozyme; RNA chaperone; RNA folding
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What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics. Juhlin, C.C., Bertherat, J., Giordano, T.J. et al. Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09667-0
Abstract:
We herein review the histological, genetic, and epigenetic landscapes of benign and malignant adrenal cortical neoplasia from a modern surgical endocrine pathology perspective and highlight key mechanisms of value for diagnostic and prognostic purposes.
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Single-Molecule Investigation of Cooperativity within the Glycine Tandem Riboswitch, Rosa A.Romero, Adrien Chauvier, Nils G.Walter, Biophysical Journal, Volume 120, Issue 3, Supplement 1, 12 February 2021, Page 312a, https://doi.org/10.1016/j.bpj.2020.11.1978
Abstract:
Riboswitches are genetic regulatory elements located in the 5’ untranslated region of bacterial messenger RNAs (mRNAs). Riboswitches contains two RNA domains that function in concert to regulate gene expression levels in response to changing cellular conditions. Tandem riboswitches are particularly interesting because they can have more sophisticated mechanisms for gene regulation to respond to a broader range of conditions. However, many of the mechanisms they utilize for gene regulation remain unclear.
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