Greetings!

As we reflect this holiday season, I am grateful for your contributions that made this year of growth possible. Your belief in a better future for cancer patients and your willingness to contribute pushes cancer research forward and lays the foundation for a better future for all of us. As we celebrate this time of giving, I am proud to share just some of the lasting impact your generosity made possible in 2025. This year, CARES:



• Partnered with award-winning actor Gary Sinise to fund chordoma cancer research at MD Anderson in honor of Gary's son, Mac Sinise. This immunotherapy study has the potential to apply to other cancers, including breast, lung, colon, and prostate tumors. The first clinical trials of these new therapies for chordoma patients will begin in 2026.

• Expanded our network of Healthcare Partners to support two new organizations, OU Health Stephenson Cancer Center and UT Southwestern Harold C. Simmons Comprehensive Cancer Center. Both institutions have the distinction of being the only NCI-Designated Cancer Centers in their respective regions, the state of Oklahoma and North Texas.

• Celebrated a milestone of half a million dollars raised since 2022 through Sk8 to Elimin8 Cancer® at Snoopy's Home Ice, supporting Providence Santa Rosa Memorial and the North Bay Cancer Alliance. Our contributions are made in honor of Santa Rosa icon Charles M. Schulz, the creator of the Peanuts®.

• Continued our funding of the TheraBionic P1 device at Karmanos Cancer Institute, an FDA-approved at-home treatment device for liver cancer, using electromagnetic fields to block the growth of tumor cells without affecting healthy tissue.

• Reinvested in our travel funds with Adirondack Health in Lake Placid, New York, and Cancer Connection in Juneau, Alaska, helping patients in remote communities reach their lifesaving cancer treatments.

• Expanded our commitment to finding effective treatments for glioblastoma, funding a Transcriptome-Wide Association Study (TWAS) at the single-cell level through Vanderbilt University Medical Center. This research will deepen the understanding of the molecular makeup of these brain tumors to develop effective targeted therapies.

As 2025 draws to a close, we celebrate our shared impact in the cancer community and look forward to continuing to advance cancer care in 2026. Thank you for being an integral part of our community and a positive force in the lives of those affected by cancer.

With the spirit of giving in the air, I invite you to consider a year-end contribution to support cancer research. Together, let's continue to invest in research, inspire hope, and gift survivorship this holiday season and beyond.

My best wishes to you and yours for a happy holiday season and a blessed New Year.

With gratitude,